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    Tbcb Tubulin-binding cofactor B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbcbprovided by FlyBase
    Official Full Name
    Tubulin-binding cofactor Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034451
    Locus tag
    Dmel_CG11242
    See related
    AllianceGenome:FB:FBgn0034451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11242; Dmel\CG11242; dTBCB; tbcb; TBCB
    Summary
    Predicted to enable microtubule plus-end binding activity. Involved in cytoplasmic microtubule organization; establishment of apical/basal cell polarity; and oocyte axis specification. Located in cell cortex; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including ganglia; lateral cord neurons; mesoderm; and primordial germ cell. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tbcb in Genome Data Viewer
    Location:
    56D11-56D12; 2-89 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19485494..19486837, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15372999..15374342, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene meiotic W68 Neighboring gene par-1 Neighboring gene Outer segment 6 Neighboring gene Rab escort protein Neighboring gene hippo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila tubulin-binding cofactor B is required for microtubule network formation and for cell polarity. Baffet AD, et al. Mol Biol Cell, 2012 Sep. PMID 22855530, Free PMC Article
    2. Actomyosin contraction during cellularization is regulated in part by Src64 control of Actin 5C protein levels. Carter TY, et al. Genesis, 2019 Jun. PMID 30974046
    3. Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis. Okumura M, et al. J Neurosci, 2015 Feb 4. PMID 25653356, Free PMC Article
    4. The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression. Li T, et al. J Biol Chem, 2015 Jul 17. PMID 25953899, Free PMC Article
    5. Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Gogia N, et al. Neurobiol Dis, 2020 Jul. PMID 32199908, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tubulin-binding cofactor B
    Names
    CG11242-PA
    Tbcb-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19485494..19486837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137581.4 → NP_611425.1  Tubulin-binding cofactor B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBM2, Q7K1S6
      Related
      FBpp0085690
      Conserved Domains (2) summary
      cd01789
      Location:12 → 95
      Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
      pfam01302
      Location:161 → 225
      CAP_GLY; CAP-Gly domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBM2 A1ZBM2
    Q7K1S6 Q7K1S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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