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    Ttc3 tetratricopeptide repeat domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 22129, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttc3provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 3provided by MGI
    Primary source
    MGI:MGI:1276539
    See related
    Ensembl:ENSMUSG00000040785 AllianceGenome:MGI:1276539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TPRD; D16Ium21; D16Ium21e; mKIAA4119; 2610202A04Rik
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of axon extension and negative regulation of neuron differentiation. Located in vacuole. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TTC3 (tetratricopeptide repeat domain 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 35.1), whole brain E14.5 (RPKM 30.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttc3 in Genome Data Viewer
    Location:
    16 C4; 16 55.18 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94171479..94270081)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94370625..94469222)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5565 Neighboring gene predicted gene, 53180 Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P Neighboring gene predicted gene, 23692 Neighboring gene predicted gene, 31323 Neighboring gene STARR-positive B cell enhancer ABC_E1498 Neighboring gene VPS26 endosomal protein sorting factor C Neighboring gene STARR-positive B cell enhancer ABC_E9431 Neighboring gene STARR-seq mESC enhancer starr_41576 Neighboring gene STARR-seq mESC enhancer starr_41578 Neighboring gene STARR-positive B cell enhancer ABC_E5566 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 1a Neighboring gene STARR-positive B cell enhancer mm9_chr16:94853523-94853824 Neighboring gene predicted gene, 53922

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome. Tsukahara F, et al. J Biochem, 1998 Jun. PMID 9603993
    2. Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1. Lopes C, et al. Mech Dev, 1999 Jun. PMID 10473140
    3. Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3. Endo R, et al. Proc Natl Acad Sci U S A, 2023 Mar 21. PMID 36917672, Free PMC Article
    4. An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome. Guedj F, et al. Sci Rep, 2016 Sep 2. PMID 27586445, Free PMC Article
    5. The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. Berto G, et al. J Cell Sci, 2007 Jun 1. PMID 17488780

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.
      Title: Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.
    2. USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome.
      Title: An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.
    3. These results suggest that the TTC3-RhoA-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.
      Title: The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4119

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TTC3
    Names
    RING-type E3 ubiquitin transferase TTC3
    TPR repeat protein D
    mtprd
    NP_033467.2
    XP_006523047.1
    XP_006523048.1
    XP_006523049.1
    XP_006523050.1
    XP_006523051.1
    XP_006523052.1
    XP_006523053.1
    XP_006523054.1
    XP_006523055.1
    XP_006523056.1
    XP_006523057.1
    XP_006523058.1
    XP_006523059.1
    XP_006523060.1
    XP_006523062.1
    XP_006523063.1
    XP_011244415.1
    XP_017172428.1
    XP_017172429.1
    XP_017172430.1
    XP_017172431.1
    XP_030104906.1
    XP_030104907.1
    XP_030104908.1
    XP_030104909.1
    XP_030104910.1
    XP_030104911.1
    XP_030104912.1
    XP_030104913.1
    XP_030104914.1
    XP_030104915.1
    XP_030104916.1
    XP_030104917.1
    XP_030104918.1
    XP_030104919.1
    XP_030104921.1
    XP_036015769.1
    XP_036015770.1
    XP_036015771.1
    XP_036015772.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009441.2 → NP_033467.2  E3 ubiquitin-protein ligase TTC3

      See identical proteins and their annotated locations for NP_033467.2

      Status: VALIDATED

      Source sequence(s)
      AC173208
      Consensus CDS
      CCDS37407.1
      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      UniProtKB/TrEMBL
      G5E8T2
      Related
      ENSMUSP00000112801.2, ENSMUST00000117648.9
      Conserved Domains (5) summary
      PTZ00121
      Location:1460 → 1694
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:237 → 381
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:232 → 259
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1930 → 1970
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:578 → 605
      TPR_1; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      94171479..94270081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522997.5 → XP_006523060.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      See identical proteins and their annotated locations for XP_006523060.1

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    2. XM_006522995.4 → XP_006523058.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      See identical proteins and their annotated locations for XP_006523058.1

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    3. XM_006523000.5 → XP_006523063.1  E3 ubiquitin-protein ligase TTC3 isoform X15

      See identical proteins and their annotated locations for XP_006523063.1

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (5) summary
      PTZ00121
      Location:974 → 1208
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1444 → 1484
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat

    4. XM_006522999.4 → XP_006523062.1  E3 ubiquitin-protein ligase TTC3 isoform X15

      See identical proteins and their annotated locations for XP_006523062.1

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (5) summary
      PTZ00121
      Location:974 → 1208
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1444 → 1484
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat

    5. XM_006522992.4 → XP_006523055.1  E3 ubiquitin-protein ligase TTC3 isoform X9

      See identical proteins and their annotated locations for XP_006523055.1

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (6) summary
      PTZ00121
      Location:1330 → 1564
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:107 → 251
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:102 → 129
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:410 → 472
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1800 → 1840
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:448 → 475
      TPR_1; Tetratricopeptide repeat

    6. XM_017316939.3 → XP_017172428.1  E3 ubiquitin-protein ligase TTC3 isoform X11

      UniProtKB/TrEMBL
      A0A338P6W3
      Related
      ENSMUSP00000156137.2, ENSMUST00000231569.2
      Conserved Domains (5) summary
      PTZ00121
      Location:1150 → 1384
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:181 → 208
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:230 → 292
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1620 → 1660
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:268 → 295
      TPR_1; Tetratricopeptide repeat

    7. XM_030249047.2 → XP_030104907.1  E3 ubiquitin-protein ligase TTC3 isoform X12

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (5) summary
      PTZ00121
      Location:1149 → 1383
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:181 → 208
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:230 → 292
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1619 → 1659
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:268 → 295
      TPR_1; Tetratricopeptide repeat

    8. XM_006522996.4 → XP_006523059.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      See identical proteins and their annotated locations for XP_006523059.1

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    9. XM_030249055.2 → XP_030104915.1  E3 ubiquitin-protein ligase TTC3 isoform X14

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1058 → 1292
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1528 → 1568
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    10. XM_006522988.3 → XP_006523051.1  E3 ubiquitin-protein ligase TTC3 isoform X6

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (5) summary
      PTZ00121
      Location:1459 → 1693
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:237 → 381
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:232 → 259
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1929 → 1969
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:578 → 605
      TPR_1; Tetratricopeptide repeat

    11. XM_006522989.4 → XP_006523052.1  E3 ubiquitin-protein ligase TTC3 isoform X7

      See identical proteins and their annotated locations for XP_006523052.1

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (5) summary
      PTZ00121
      Location:1442 → 1676
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:219 → 363
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:214 → 241
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1912 → 1952
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:560 → 587
      TPR_1; Tetratricopeptide repeat

    12. XM_006522990.2 → XP_006523053.1  E3 ubiquitin-protein ligase TTC3 isoform X8

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (5) summary
      PTZ00121
      Location:1441 → 1675
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:219 → 363
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:214 → 241
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1911 → 1951
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:560 → 587
      TPR_1; Tetratricopeptide repeat

    13. XM_006522994.3 → XP_006523057.1  E3 ubiquitin-protein ligase TTC3 isoform X11

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (5) summary
      PTZ00121
      Location:1150 → 1384
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:181 → 208
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:230 → 292
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1620 → 1660
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:268 → 295
      TPR_1; Tetratricopeptide repeat

    14. XM_017316940.2 → XP_017172429.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    15. XM_030249061.1 → XP_030104921.1  E3 ubiquitin-protein ligase TTC3 isoform X16

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:973 → 1207
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1443 → 1483
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:136 → 251
      DUF5861; Family of unknown function (DUF5861)

    16. XM_006522984.4 → XP_006523047.1  E3 ubiquitin-protein ligase TTC3 isoform X1

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (5) summary
      PTZ00121
      Location:1479 → 1713
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:256 → 400
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:251 → 278
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1949 → 1989
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:597 → 624
      TPR_1; Tetratricopeptide repeat

    17. XM_006522985.1 → XP_006523048.1  E3 ubiquitin-protein ligase TTC3 isoform X3

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (5) summary
      PTZ00121
      Location:1479 → 1712
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:256 → 400
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:251 → 278
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1948 → 1988
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:597 → 624
      TPR_1; Tetratricopeptide repeat

    18. XM_006522986.1 → XP_006523049.1  E3 ubiquitin-protein ligase TTC3 isoform X2

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (5) summary
      PTZ00121
      Location:1478 → 1712
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:256 → 400
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:251 → 278
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1948 → 1988
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:597 → 624
      TPR_1; Tetratricopeptide repeat

    19. XM_036159877.1 → XP_036015770.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    20. XM_017316941.2 → XP_017172430.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    21. XM_030249056.2 → XP_030104916.1  E3 ubiquitin-protein ligase TTC3 isoform X14

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1058 → 1292
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1528 → 1568
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    22. XM_017316942.2 → XP_017172431.1  E3 ubiquitin-protein ligase TTC3 isoform X16

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:973 → 1207
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1443 → 1483
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:136 → 251
      DUF5861; Family of unknown function (DUF5861)

    23. XM_030249054.1 → XP_030104914.1  E3 ubiquitin-protein ligase TTC3 isoform X14

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1058 → 1292
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1528 → 1568
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    24. XM_006522993.3 → XP_006523056.1  E3 ubiquitin-protein ligase TTC3 isoform X10

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (6) summary
      PTZ00121
      Location:1312 → 1546
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:89 → 233
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:84 → 111
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:392 → 454
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1782 → 1822
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:430 → 457
      TPR_1; Tetratricopeptide repeat

    25. XM_006522987.3 → XP_006523050.1  E3 ubiquitin-protein ligase TTC3 isoform X4

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (5) summary
      PTZ00121
      Location:1461 → 1695
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:238 → 382
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:233 → 260
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1931 → 1971
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:579 → 606
      TPR_1; Tetratricopeptide repeat

    26. XM_030249048.1 → XP_030104908.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    27. XM_036159878.1 → XP_036015771.1  E3 ubiquitin-protein ligase TTC3 isoform X14

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1058 → 1292
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1528 → 1568
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    28. XM_030249057.1 → XP_030104917.1  E3 ubiquitin-protein ligase TTC3 isoform X15

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (5) summary
      PTZ00121
      Location:974 → 1208
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1444 → 1484
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat

    29. XM_036159879.1 → XP_036015772.1  E3 ubiquitin-protein ligase TTC3 isoform X16

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:973 → 1207
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1443 → 1483
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:136 → 251
      DUF5861; Family of unknown function (DUF5861)

    30. XM_030249050.1 → XP_030104910.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    31. XM_030249052.1 → XP_030104912.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    32. XM_030249058.1 → XP_030104918.1  E3 ubiquitin-protein ligase TTC3 isoform X15

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (5) summary
      PTZ00121
      Location:974 → 1208
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1444 → 1484
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat

    33. XM_030249051.1 → XP_030104911.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    34. XM_030249059.1 → XP_030104919.1  E3 ubiquitin-protein ligase TTC3 isoform X15

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (5) summary
      PTZ00121
      Location:974 → 1208
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:5 → 32
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:54 → 116
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1444 → 1484
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:92 → 119
      TPR_1; Tetratricopeptide repeat

    35. XM_006522991.3 → XP_006523054.1  E3 ubiquitin-protein ligase TTC3 isoform X9

      See identical proteins and their annotated locations for XP_006523054.1

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (6) summary
      PTZ00121
      Location:1330 → 1564
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:107 → 251
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:102 → 129
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:410 → 472
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1800 → 1840
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:448 → 475
      TPR_1; Tetratricopeptide repeat

    36. XM_030249046.1 → XP_030104906.1  E3 ubiquitin-protein ligase TTC3 isoform X10

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      Conserved Domains (6) summary
      PTZ00121
      Location:1312 → 1546
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:89 → 233
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:84 → 111
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:392 → 454
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1782 → 1822
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:430 → 457
      TPR_1; Tetratricopeptide repeat

    37. XM_030249049.1 → XP_030104909.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    38. XM_036159876.1 → XP_036015769.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    39. XM_030249053.1 → XP_030104913.1  E3 ubiquitin-protein ligase TTC3 isoform X13

      UniProtKB/TrEMBL
      A0A338P6W3
      Conserved Domains (6) summary
      PTZ00121
      Location:1059 → 1293
      PTZ00121; MAEBL; Provisional
      sd00006
      Location:90 → 117
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:139 → 201
      TPR_12; Tetratricopeptide repeat
      cd16481
      Location:1529 → 1569
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:177 → 204
      TPR_1; Tetratricopeptide repeat
      pfam19179
      Location:221 → 336
      DUF5861; Family of unknown function (DUF5861)

    40. XM_011246113.4 → XP_011244415.1  E3 ubiquitin-protein ligase TTC3 isoform X5

      See identical proteins and their annotated locations for XP_011244415.1

      UniProtKB/Swiss-Prot
      O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
      UniProtKB/TrEMBL
      G5E8T2
      Related
      ENSMUSP00000156023.2, ENSMUST00000232395.2
      Conserved Domains (5) summary
      PTZ00121
      Location:1460 → 1694
      PTZ00121; MAEBL; Provisional
      PLN03088
      Location:237 → 381
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:232 → 259
      TPR; TPR repeat [structural motif]
      cd16481
      Location:1930 → 1970
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
      pfam00515
      Location:578 → 605
      TPR_1; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88196.2 GenPept UniProtKB/Swiss-Prot:O88196

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