Acbd5 acyl-Coenzyme A binding domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acbd5provided by MGI
Official Full Name: acyl-Coenzyme A binding domain containing 5provided by MGI
Primary source: MGI:MGI:1921409
See related: Ensembl:ENSMUSG00000026781 AllianceGenome:MGI:1921409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300014E15Rik
Summary: Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process and pexophagy. Predicted to be located in nucleoplasm. Predicted to be active in peroxisome. Is expressed in several structures, including nervous system and sensory organ. Used to study peroxisomal disease. Human ortholog(s) of this gene implicated in retinal dystrophy with leukodystrophy. Orthologous to human ACBD5 (acyl-CoA binding domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 8.7), frontal lobe adult (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 15.21 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (22958189..23004525)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (23068166..23114513)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis.
Title: Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit465 (e-PCR), detects polymorphism
- UniSTS:129376

UniSTS:234876 (e-PCR)
- UniSTS:234876

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pexophagy	IEA Inferred from Electronic Annotation more info
involved_in pexophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-CoA-binding domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102436.2 → NP_001095906.1 acyl-CoA-binding domain-containing protein 5 isoform d

See identical proteins and their annotated locations for NP_001095906.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction compared to variant 5. The resulting isoform (c) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform e.

Source sequence(s)

AL845257

Consensus CDS

CCDS50516.1

UniProtKB/TrEMBL

Q5CZX6

Related

ENSMUSP00000154023.2, ENSMUST00000227809.2

Conserved Domains (1) summary

cd00435
Location:9 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001102437.1 → NP_001095907.1 acyl-CoA-binding domain-containing protein 5 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform e.

Source sequence(s)

AK005001, AK147839, BC090641, BY126800

Consensus CDS

CCDS57156.1

UniProtKB/TrEMBL

E9QNH7, Q5CZX6

Related

ENSMUSP00000110175.3, ENSMUST00000114529.10

Conserved Domains (1) summary

cd00435
Location:45 → 132

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001102438.1 → NP_001095908.1 acyl-CoA-binding domain-containing protein 5 isoform b

See identical proteins and their annotated locations for NP_001095908.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 5. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform e.

Source sequence(s)

AK050450, AK147839, BC090641, BY126800

Consensus CDS

CCDS50514.1

UniProtKB/Swiss-Prot

A2AQX9, A2AQY0, Q5XG73, Q6P7V7, Q7TSC2, Q8BKU6, Q8CI99, Q9CW41

UniProtKB/TrEMBL

Q5CZX6

Related

ENSMUSP00000110172.2, ENSMUST00000114526.9

Conserved Domains (1) summary

cd00435
Location:45 → 132

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001355637.1 → NP_001342566.1 acyl-CoA-binding domain-containing protein 5 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (e).

Source sequence(s)

AL845257

Consensus CDS

CCDS89434.1

UniProtKB/TrEMBL

A0A2I3BQ50, Q5CZX6

Related

ENSMUSP00000154043.2, ENSMUST00000228050.2

Conserved Domains (1) summary

cd00435
Location:45 → 132

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001355638.1 → NP_001342567.1 acyl-CoA-binding domain-containing protein 5 isoform f

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is 1 aa shorter compared to isoform e.

Source sequence(s)

AL845257

Consensus CDS

CCDS89435.1

UniProtKB/TrEMBL

A0A2I3BQH8, Q5CZX6

Related

ENSMUSP00000154188.2, ENSMUST00000226571.2

Conserved Domains (1) summary

cd00435
Location:45 → 132

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001355639.2 → NP_001342568.1 acyl-CoA-binding domain-containing protein 5 isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 5. The resulting isoform (g) is shorter at the N-terminus and lacks an internal single aa compared to isoform e.

Source sequence(s)

AL845257

Consensus CDS

CCDS89437.1

UniProtKB/TrEMBL

A0A2I3BRB9, Q5CZX6

Related

ENSMUSP00000154518.2, ENSMUST00000227663.2

Conserved Domains (1) summary

cd00435
Location:9 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001355641.1 → NP_001342570.1 acyl-CoA-binding domain-containing protein 5 isoform h

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an alternate exon in the 5' end compared to variant 5. The resulting isoform (h) is shorter at the N-terminus compared to isoform e.

Source sequence(s)

AL845257

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001355642.1 → NP_001342571.1 acyl-CoA-binding domain-containing protein 5 isoform i

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (i) is shorter at the N-terminus and lacks an alternate segment compared to isoform e.

Source sequence(s)

AL845257

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
NM_001406433.1 → NP_001393362.1 acyl-CoA-binding domain-containing protein 5 isoform d

Status: VALIDATED

Source sequence(s)

AL845257
NM_001406434.1 → NP_001393363.1 acyl-CoA-binding domain-containing protein 5 isoform g

Status: VALIDATED

Source sequence(s)

AL845257

UniProtKB/TrEMBL

A0A2I3BRB9
NM_001406435.1 → NP_001393364.1 acyl-CoA-binding domain-containing protein 5 isoform h

Status: VALIDATED

Source sequence(s)

AL845257
NM_001406436.1 → NP_001393365.1 acyl-CoA-binding domain-containing protein 5 isoform i

Status: VALIDATED

Source sequence(s)

AL845257
NM_001406437.1 → NP_001393366.1 acyl-CoA-binding domain-containing protein 5 isoform i

Status: VALIDATED

Source sequence(s)

AL845257
NM_001406438.1 → NP_001393367.1 acyl-CoA-binding domain-containing protein 5 isoform j

Status: VALIDATED

Source sequence(s)

AL845257

UniProtKB/TrEMBL

Z4YM84
NM_001406439.1 → NP_001393368.1 acyl-CoA-binding domain-containing protein 5 isoform j

Status: VALIDATED

Source sequence(s)

AL845257

UniProtKB/TrEMBL

Z4YM84

Related

ENSMUSP00000117325.3, ENSMUST00000155602.4
NM_001406440.1 → NP_001393369.1 acyl-CoA-binding domain-containing protein 5 isoform k

Status: VALIDATED

Source sequence(s)

AL845257
NM_001406441.1 → NP_001393370.1 acyl-CoA-binding domain-containing protein 5 isoform k

Status: VALIDATED

Source sequence(s)

AL845257
NM_001406442.1 → NP_001393371.1 acyl-CoA-binding domain-containing protein 5 isoform l

Status: VALIDATED

Source sequence(s)

AL845257
NM_028793.4 → NP_083069.1 acyl-CoA-binding domain-containing protein 5 isoform c

See identical proteins and their annotated locations for NP_083069.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform e.

Source sequence(s)

AL845257

Consensus CDS

CCDS50515.1

UniProtKB/TrEMBL

Q5CZX6

Related

ENSMUSP00000028121.9, ENSMUST00000028121.15

Conserved Domains (1) summary

cd00435
Location:9 → 96

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

RNA

NR_149742.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in the 5' end and has multiple internal differences compared to variant 5. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL845257
NR_176074.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257
NR_176075.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257
NR_176076.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257
NR_176077.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257
NR_176078.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257
NR_176079.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257
NR_176080.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257
NR_176081.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845257

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

22958189..23004525

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162633.1 → XP_036018526.1 acyl-CoA-binding domain-containing protein 5 isoform X4

Conserved Domains (1) summary

cl00221
Location:1 → 22

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...