Themis2 thymocyte selection associated family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Themis2provided by MGI
Official Full Name: thymocyte selection associated family member 2provided by MGI
Primary source: MGI:MGI:2446213
See related: Ensembl:ENSMUSG00000037731 AllianceGenome:MGI:2446213
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ICB-1
Summary: Involved in regulation of B cell activation. Acts upstream of or within T cell receptor signaling pathway. Located in cytoplasm and nucleus. Orthologous to human THEMIS2 (thymocyte selection associated family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 22.6), mammary gland adult (RPKM 8.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 65.9 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (132509148..132523675, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (132781843..132796364, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling.
Title: THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling.
Themis2 regulates natural killer cell memory function and formation.
Title: Themis2 regulates natural killer cell memory function and formation.
this stuidy identifies a unique function for Themis2 in differential signaling and provide insight into how B cells discriminate between antigens of different quantity and quality
Title: Themis2 lowers the threshold for B cell activation during positive selection.
Data indicate that Themis2 protein is not required for B cell development, for activation, or for antibody responses either to model Ags or to influenza viral infection.
Title: Themis2 is not required for B cell development, activation, and antibody responses.
Study hypothesise that Themis2 may constitute a novel, physiological control point in macrophage inflammatory responses.
Title: Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein THEMIS2

Names: basement membrane-induced protein; induced by contact to basement membrane 1 protein; protein ICB-1; thymocyte-expressed molecule involved in selection protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033308.2 → NP_001028480.1 protein THEMIS2

See identical proteins and their annotated locations for NP_001028480.1

Status: PROVISIONAL

Source sequence(s)

AK150471

Consensus CDS

CCDS18735.1

UniProtKB/Swiss-Prot

Q3U5K5, Q91YX0

Related

ENSMUSP00000036945.6, ENSMUST00000045154.6

Conserved Domains (1) summary

pfam12736
Location:264 → 520

CABIT; Cell-cycle sustaining, positive selection,

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

132509148..132523675 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250230.4 → XP_011248532.1 protein THEMIS2 isoform X1

Conserved Domains (1) summary

pfam12736
Location:165 → 421

CABIT; Cell-cycle sustaining, positive selection,