Dcbld2 discoidin, CUB and LCCL domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcbld2provided by MGI
Official Full Name: discoidin, CUB and LCCL domain containing 2provided by MGI
Primary source: MGI:MGI:1920629
See related: Ensembl:ENSMUSG00000035107 AllianceGenome:MGI:1920629
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Esdn; CLCP1; 1700055P21Rik
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of cell growth and wound healing. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human DCBLD2 (discoidin, CUB and LCCL domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 10.6), CNS E11.5 (RPKM 10.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.2; 16 34.52 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (58228789..58304013)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (58408535..58469745)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
Title: CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-beta endocytosis through Caveolin-1 in vascular smooth muscle cells.
Title: DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-β endocytosis through Caveolin-1 in vascular smooth muscle cells.
ESDN regulates insulin signaling and subsequently a wide array of insulin effects in cultured cells and in vivo through modulation of IR interaction with APS and Grb10.
Title: The neuropilin-like protein ESDN regulates insulin signaling and sensitivity.
Deletion of Esdn in the mouse interfered with adult and developmental angiogenesis.
Title: Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140710 (e-PCR)
- UniSTS:222776

AI930218 (e-PCR)
- UniSTS:166008

RH126271 (e-PCR)
- UniSTS:162979

RH66607 (e-PCR)
- UniSTS:8108

NoName (e-PCR)
- UniSTS:237524

AW146002 (e-PCR)
- UniSTS:186077

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: discoidin, CUB and LCCL domain-containing protein 2

Names: endothelial and smooth muscle cell-derived neuropilin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356484.1 → NP_001343413.1 discoidin, CUB and LCCL domain-containing protein 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CT027564

Conserved Domains (3) summary

cd00041
Location:69 → 183

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:293 → 445

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl02694
Location:190 → 272

LCCL; LCCL domain
NM_028523.3 → NP_082799.2 discoidin, CUB and LCCL domain-containing protein 2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AK043915, AK051889, AK052189, BC066097, CAAA01184608

Consensus CDS

CCDS28229.1

UniProtKB/Swiss-Prot

A6X950, Q8BKI4, Q91ZV3

Related

ENSMUSP00000039915.8, ENSMUST00000046663.8

Conserved Domains (4) summary

smart00231
Location:288 → 446

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:69 → 183

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:293 → 445

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl02694
Location:190 → 272

LCCL; LCCL domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

58228789..58304013

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160148.1 → XP_036016041.1 discoidin, CUB and LCCL domain-containing protein 2 isoform X1

Conserved Domains (3) summary

cd00041
Location:69 → 183

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl25480
Location:293 → 400

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl02694
Location:190 → 272

LCCL; LCCL domain
XM_036160149.1 → XP_036016042.1 discoidin, CUB and LCCL domain-containing protein 2 isoform X2

Conserved Domains (3) summary

cd00041
Location:69 → 183

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl25480
Location:293 → 400

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl02694
Location:190 → 272

LCCL; LCCL domain
XM_011246022.3 → XP_011244324.1 discoidin, CUB and LCCL domain-containing protein 2 isoform X3

Conserved Domains (3) summary

cd00057
Location:217 → 369

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl00049
Location:66 → 107

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl02694
Location:114 → 196

LCCL; LCCL domain