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    Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB [ Mus musculus (house mouse) ]

    Gene ID: 544971, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bdp1provided by MGI
    Official Full Name
    B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIBprovided by MGI
    Primary source
    MGI:MGI:1347077
    See related
    Ensembl:ENSMUSG00000049658 AllianceGenome:MGI:1347077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TFC5; Tfnr; TAF3B1; TFIIIB90; TFIIIB150; mKIAA1241; B130055N23Rik; G630013P12Rik
    Summary
    Predicted to enable TFIIIC-class transcription factor complex binding activity. Predicted to be involved in RNA polymerase III preinitiation complex assembly. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIB complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 112. Orthologous to human BDP1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.1), liver E14 (RPKM 2.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bdp1 in Genome Data Viewer
    Location:
    13 D1; 13 52.92 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100154502..100244524, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100017994..100104090, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41039 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 2 (beta) Neighboring gene STARR-positive B cell enhancer ABC_E1885 Neighboring gene STARR-positive B cell enhancer ABC_E2419 Neighboring gene STARR-positive B cell enhancer ABC_E3095 Neighboring gene small EDRK-rich factor 1 Neighboring gene survival motor neuron 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. Girotto G, et al. PLoS One, 2013. PMID 24312468, Free PMC Article
    2. The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1. Kelter AR, et al. Genomics, 2000 Dec 15. PMID 11161782
    3. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Diez E, et al. Nat Genet, 2003 Jan. PMID 12483212
    4. Comparative sequence analysis of the mouse and human Lgn1/SMA interval. Endrizzi M, et al. Genomics, 1999 Sep 1. PMID 10486205
    5. Genomic sequence analysis of the mouse Naip gene array. Endrizzi MG, et al. Genome Res, 2000 Aug. PMID 10958627, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.
      Title: Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1241

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TFIIIC-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase III preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor TFIIIB component B'' homolog
    Names
    transcription factor IIIB 150
    transcription factor-like nuclear regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081061.1 → NP_001074530.1  transcription factor TFIIIB component B'' homolog

      See identical proteins and their annotated locations for NP_001074530.1

      Status: VALIDATED

      Source sequence(s)
      CT025569, CT030167
      Consensus CDS
      CCDS49343.1
      UniProtKB/Swiss-Prot
      Q571C7, Q8BTI4, Q8K0U7
      Related
      ENSMUSP00000038321.6, ENSMUST00000038104.12
      Conserved Domains (2) summary
      COG5118
      Location:93 → 416
      BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
      pfam15963
      Location:299 → 382
      Myb_DNA-bind_7; Myb DNA-binding like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100154502..100244524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158096.1 → XP_036013989.1  transcription factor TFIIIB component B'' homolog isoform X6

    2. XM_017315546.2 → XP_017171035.1  transcription factor TFIIIB component B'' homolog isoform X1

      Conserved Domains (2) summary
      COG5118
      Location:93 → 415
      BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
      pfam15963
      Location:298 → 381
      Myb_DNA-bind_7; Myb DNA-binding like

    3. XM_036158094.1 → XP_036013987.1  transcription factor TFIIIB component B'' homolog isoform X4

      Conserved Domains (2) summary
      COG5118
      Location:93 → 426
      BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
      pfam15963
      Location:295 → 379
      Myb_DNA-bind_7; Myb DNA-binding like

    4. XM_036158093.1 → XP_036013986.1  transcription factor TFIIIB component B'' homolog isoform X3

      Conserved Domains (2) summary
      COG5118
      Location:93 → 426
      BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
      pfam15963
      Location:295 → 379
      Myb_DNA-bind_7; Myb DNA-binding like

    5. XM_017315545.3 → XP_017171034.1  transcription factor TFIIIB component B'' homolog isoform X2

      Conserved Domains (2) summary
      COG5118
      Location:93 → 416
      BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
      pfam15963
      Location:299 → 382
      Myb_DNA-bind_7; Myb DNA-binding like

    6. XM_036158097.1 → XP_036013990.1  transcription factor TFIIIB component B'' homolog isoform X6

    7. XM_036158095.1 → XP_036013988.1  transcription factor TFIIIB component B'' homolog isoform X5

      Conserved Domains (1) summary
      pfam15963
      Location:40 → 124
      Myb_DNA-bind_7; Myb DNA-binding like

    RNA

    1. XR_382739.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q571C7.2 GenPept UniProtKB/Swiss-Prot:Q571C7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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