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    BBC1 Bbc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BBC1
    Official Full Name
    Bbc1p
    Primary source
    SGD:S000003557
    Locus tag
    YJL020C
    See related
    AllianceGenome:SGD:S000003557; FungiDB:YJL020C; VEuPathDB:YJL020C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MTI1; YJL021C
    Summary
    Enables myosin I tail binding activity. Involved in actin cytoskeleton organization and negative regulation of Arp2/3 complex-mediated actin nucleation. Is active in actin cortical patch. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BBC1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (398937..402410, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Pet130p Neighboring gene Mps3p Neighboring gene Tph3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type-I myosins promote actin polymerization to drive membrane bending in endocytosis. Manenschijn HE, et al. Elife, 2019 Aug 6. PMID 31385806, Free PMC Article
    2. Actin-generated force applied during endocytosis measured by Sla2-based FRET tension sensors. Abella M, et al. Dev Cell, 2021 Sep 13. PMID 34473942
    3. Disruption of six open reading frames on chromosome X of Saccharomyces cerevisiae reveals a cluster of four essential genes. Esser K, et al. Yeast, 1999 Jul. PMID 10407272
    4. Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. Vilella F, et al. J Biol Chem, 2005 Mar 11. PMID 15637049
    5. Negative regulation of yeast WASp by two SH3 domain-containing proteins. Rodal AA, et al. Curr Biol, 2003 Jun 17. PMID 12814545

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mtl1 is characterized for as a cell-wall sensor of oxidative stress.
      Title: Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables myosin I tail binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin I tail binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Bbc1p
    NP_012514.2
    • Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      398937..402410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181454.1 → NP_012514.2  TPA: Bbc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012514.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWG0, P47067, P47068, Q8X1F4
      UniProtKB/TrEMBL
      A6ZPV2, N1P0Y5
      Conserved Domains (2) summary
      cd11887
      Location:7 → 66
      SH3_Bbc1; Src Homology 3 domain of Bbc1 and similar domains
      TIGR03835
      Location:38 → 386
      termin_org_DnaJ; terminal organelle assembly protein TopJ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47068.2

    Gene LinkOut

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