Ifnar1 interferon (alpha and beta) receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifnar1provided by MGI
Official Full Name: interferon (alpha and beta) receptor 1provided by MGI
Primary source: MGI:MGI:107658
See related: Ensembl:ENSMUSG00000022967 AllianceGenome:MGI:107658
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifar; Ifrc; Ifnar; Infar
Summary: Enables type I interferon binding activity and type I interferon receptor activity. Involved in several processes, including cellular response to interferon-alpha; defense response to symbiont; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within T cell activation; positive regulation of cytokine production; and regulation of peptidyl-tyrosine phosphorylation. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis C and primary immunodeficiency disease. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 8.7), CNS E18 (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 52.98 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91281016..91307411)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (91485032..91510523)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua.
Title: Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua.
Pathological and virological findings of type I interferon receptor knockout mice upon experimental infection with Heartland virus.
Title: Pathological and virological findings of type I interferon receptor knockout mice upon experimental infection with Heartland virus.
Age- and Sex-Associated Pathogenesis of Cell Culture-Passaged Kemerovo Virus in IFNAR[(-/-)] Mice.
Title: Age- and Sex-Associated Pathogenesis of Cell Culture-Passaged Kemerovo Virus in IFNAR((-/-)) Mice.
Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus.
Title: Cytokine mRNA Expression Profile in Target Organs of IFNAR (-/-) Mice Infected with African Horse Sickness Virus.
Tissue factor binds to and inhibits interferon-alpha receptor 1 signaling.
Title: Tissue factor binds to and inhibits interferon-α receptor 1 signaling.
Murine Mast Cells That Are Deficient in IFNAR-Signaling Respond to Viral Infection by Producing a Large Amount of Inflammatory Cytokines, a Low Level of Reactive Oxygen Species, and a High Rate of Cell Death.
Title: Murine Mast Cells That Are Deficient in IFNAR-Signaling Respond to Viral Infection by Producing a Large Amount of Inflammatory Cytokines, a Low Level of Reactive Oxygen Species, and a High Rate of Cell Death.
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity.
Title: Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity.
The infectivity and pathogenicity of hepatitis A virus live-attenuated vaccine strain H2 in type I interferon receptor-deficient mice.
Title: The infectivity and pathogenicity of hepatitis A virus live-attenuated vaccine strain H2 in type I interferon receptor-deficient mice.
IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes.
Title: IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes.
Zika virus vertical transmission in interferon receptor1-antagonized Rag1(-/-) mice results in postnatal brain abnormalities and clinical disease.
Title: Zika virus vertical transmission in interferon receptor1-antagonized Rag1(-/-) mice results in postnatal brain abnormalities and clinical disease.

Submit: New GeneRIF Correction See all GeneRIFs (146)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (12) 1 citation
Targeted (7) 1 citation

General gene information

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Markers

Ifnar1 (e-PCR), detects polymorphism
- UniSTS:259090

px-65a8 (e-PCR)
- UniSTS:258110

px-72g5 (e-PCR)
- UniSTS:258181

px-24g4 (e-PCR)
- UniSTS:257458

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JAK pathway signal transduction adaptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables interferon receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables type I interferon binding	IPI Inferred from Physical Interaction more info	PubMed
enables type I interferon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type I interferon receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables type I interferon receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables type I interferon receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interferon alpha/beta receptor 1

Names: IFN-R-1; IFN-alpha/beta receptor 1; IFN-alpha/betaR; INF-a receptor; type I interferon receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010508.2 → NP_034638.2 interferon alpha/beta receptor 1 precursor

Status: VALIDATED

Source sequence(s)

AC132272, AC150035, BC052429, BE955685, CA322032

Consensus CDS

CCDS28326.1

UniProtKB/Swiss-Prot

P33896, Q80UJ3

UniProtKB/TrEMBL

Q3UFX4

Related

ENSMUSP00000023689.5, ENSMUST00000023689.11

Conserved Domains (2) summary

pfam09294
Location:126 → 224

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:335 → 422

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...