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    Qsox2 quiescin Q6 sulfhydryl oxidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 227638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qsox2provided by MGI
    Official Full Name
    quiescin Q6 sulfhydryl oxidase 2provided by MGI
    Primary source
    MGI:MGI:2387194
    See related
    Ensembl:ENSMUSG00000036327 AllianceGenome:MGI:2387194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Soxn; Qscn6l1
    Summary
    This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell death. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 20.9), ovary adult (RPKM 12.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Qsox2 in Genome Data Viewer
    Location:
    2 A3; 2 18.45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26099136..26127411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26209124..26237399, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35745 Neighboring gene STARR-seq mESC enhancer starr_03976 Neighboring gene LIM homeobox protein 3 Neighboring gene STARR-seq mESC enhancer starr_03977 Neighboring gene STARR-positive B cell enhancer ABC_E10086 Neighboring gene STARR-seq mESC enhancer starr_03978 Neighboring gene predicted gene, 52504 Neighboring gene coiled-coil domain containing 187 Neighboring gene predicted gene, 35807

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin sulfhydryl oxidase 2 showed disruption of ovulatory activity in mice. Chen SY, et al. J Ovarian Res, 2024 Mar 19. PMID 38504307, Free PMC Article
    2. Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/Quiescin6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. Wittke I, et al. Cancer Res, 2003 Nov 15. PMID 14633699
    3. Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with segment-specific sperm surface associations. Wang TE, et al. Biol Reprod, 2018 Nov 1. PMID 29800099
    4. Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis. Wang TE, et al. Reproduction, 2021 Apr 20. PMID 33784244
    5. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Thorpe C, et al. Arch Biochem Biophys, 2002 Sep 1. PMID 12176051

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31729

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sulfhydryl oxidase 2
    Names
    quiescin Q6-like 1
    NP_001289885.1
    NP_705787.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302956.1 → NP_001289885.1  sulfhydryl oxidase 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001289885.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK140324, AL773595
      UniProtKB/Swiss-Prot
      A2ALE0, A2ALE1, Q3TMX7, Q3TZA5, Q8C9I4, Q8K0M2
      Conserved Domains (2) summary
      cd02992
      Location:55 → 168
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:425 → 522
      Evr1_Alr; Erv1 / Alr family

    2. NM_153559.3 → NP_705787.1  sulfhydryl oxidase 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_705787.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate terminal exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. It encodes isoform 2 which has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK157992, AL773595
      Consensus CDS
      CCDS15798.1
      UniProtKB/Swiss-Prot
      Q3TMX7
      Related
      ENSMUSP00000037128.9, ENSMUST00000036187.9
      Conserved Domains (2) summary
      cd02992
      Location:55 → 168
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:425 → 522
      Evr1_Alr; Erv1 / Alr family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26099136..26127411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TMX7.1 GenPept UniProtKB/Swiss-Prot:Q3TMX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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