Fancg Fanconi anemia, complementation group G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fancgprovided by MGI
Official Full Name: Fanconi anemia, complementation group Gprovided by MGI
Primary source: MGI:MGI:1926471
See related: Ensembl:ENSMUSG00000028453 AllianceGenome:MGI:1926471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Xrcc9
Summary: Acts upstream of or within several processes, including DNA damage response; ovarian follicle development; and spermatid development. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleolus. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in gut dorsal mesentery and reproductive system. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group G; and pancreatic cancer. Orthologous to human FANCG (FA complementation group G). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 21.5), CNS E18 (RPKM 8.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 22.97 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43002337..43010565, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43002337..43010567, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hematopoietic stem cells of Fancg-/- mice Impaired functionality and homing.
Title: Impaired functionality and homing of Fancg-deficient hematopoietic stem cells.
null mutations in Fanca or Fancg are fully epistatic
Title: Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg.
the FA pathway (FancG) is not involved in regulating the outcome of SHM in mammals and it appears dispensable for class switch recombination
Title: The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.
Data show that Fancd2(-/-) mice displayed a higher magnitude of chromosomal breakage and micronucleus formation than the wild-type or Fancg(-/-) mice.
Title: Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg.
Double-mutant Fancc(-/-);Fancg(-/-) mice develop spontaneous hematologic sequelae including bone marrow failure, acute myeloid leukemia, myelodysplasia and complex random chromosomal abnormalities that the single-mutant mice do not.
Title: Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.
loss of the murine homologue of FANCG (Fancg) results in a defect in mesenchymal stem/progenitor cells proliferation and in their ability to support the adhesion and engraftment of murine syngeneic hematopoietic stem/progenitor cells in vitro or in vivo
Title: Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo.
Fancg knockout mice presented with microcephalies and a decreased neuronal production in developing cortex and adult brain, demonstrating a critical role for Fanconi pathway in neural stem and progenitor cells during developmental and adult neurogenesis.
Title: Fanconi DNA repair pathway is required for survival and long-term maintenance of neural progenitors.
Mice deficient in Fancg were not anemic, but showed hypogonadism, impaired fertility, and hypersensitivity to mitomycin C
Title: Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice.
a deletion mutation in the FANCG gene (c.637_643delTACCGCC) was present in 82% of Fanconi anemia patients in the black populations of Southern Africa
Title: A common Fanconi anemia mutation in black populations of sub-Saharan Africa.
Characterization and expression of the murine Fanconi anaemia gene product
Title: Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fancg (e-PCR), detects polymorphism
- UniSTS:548039

AU041407 (e-PCR)
- UniSTS:159229

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Fanconi anaemia nuclear complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Fanconi anaemia nuclear complex	ISO Inferred from Sequence Orthology more info
part_of Fanconi anaemia nuclear complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Fanconi anemia group G protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163233.2 → NP_001156705.1 Fanconi anemia group G protein homolog isoform 2

See identical proteins and their annotated locations for NP_001156705.1

Status: VALIDATED

Source sequence(s)

AL672276

UniProtKB/TrEMBL

A4QPC9, B9EJ17

Conserved Domains (2) summary

sd00006
Location:251 → 280

TPR; TPR repeat [structural motif]

pfam00515
Location:251 → 280

TPR_1; Tetratricopeptide repeat
NM_001426198.1 → NP_001413127.1 Fanconi anemia group G protein homolog isoform 1

Status: VALIDATED

Source sequence(s)

AL672276

UniProtKB/Swiss-Prot

A2AG34, Q9EQR6

Related

ENSMUST00000123332.8
NM_001426199.1 → NP_001413128.1 Fanconi anemia group G protein homolog isoform 1

Status: VALIDATED

Source sequence(s)

AL672276

UniProtKB/Swiss-Prot

A2AG34, Q9EQR6
NM_001426200.1 → NP_001413129.1 Fanconi anemia group G protein homolog isoform 2

Status: VALIDATED

Source sequence(s)

AL672276

UniProtKB/TrEMBL

A4QPC9
NM_001426201.1 → NP_001413130.1 Fanconi anemia group G protein homolog isoform 2

Status: VALIDATED

Source sequence(s)

AL672276

UniProtKB/TrEMBL

A4QPC9
NM_001426202.1 → NP_001413131.1 Fanconi anemia group G protein homolog isoform 3

Status: VALIDATED

Source sequence(s)

AL672276
NM_001426203.1 → NP_001413132.1 Fanconi anemia group G protein homolog isoform 4

Status: VALIDATED

Source sequence(s)

AL672276
NM_001426204.1 → NP_001413133.1 Fanconi anemia group G protein homolog isoform 4

Status: VALIDATED

Source sequence(s)

AL672276
NM_001426205.1 → NP_001413134.1 Fanconi anemia group G protein homolog isoform 5

Status: VALIDATED

Source sequence(s)

AL672276
NM_001426206.1 → NP_001413135.1 Fanconi anemia group G protein homolog isoform 5

Status: VALIDATED

Source sequence(s)

AL672276
NM_053081.3 → NP_444311.1 Fanconi anemia group G protein homolog isoform 1

See identical proteins and their annotated locations for NP_444311.1

Status: VALIDATED

Source sequence(s)

AL672276

Consensus CDS

CCDS18087.1

UniProtKB/Swiss-Prot

A2AG34, Q9EQR6

UniProtKB/TrEMBL

B9EJ17

Related

ENSMUSP00000030165.5, ENSMUST00000030165.5

Conserved Domains (2) summary

sd00006
Location:251 → 280

TPR; TPR repeat [structural motif]

pfam00515
Location:251 → 280

TPR_1; Tetratricopeptide repeat