Ciapin1 cytokine induced apoptosis inhibitor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ciapin1provided by MGI
Official Full Name: cytokine induced apoptosis inhibitor 1provided by MGI
Primary source: MGI:MGI:1922083
See related: Ensembl:ENSMUSG00000031781 AllianceGenome:MGI:1922083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: anamorsin; 2810413N20Rik
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and iron ion binding activity. Acts upstream of or within hemopoiesis and negative regulation of apoptotic process. Located in cytoplasm and nucleolus. Is expressed in several structures, including ganglia; sensory organ; submandibular gland primordium; tooth; and urinary system. Orthologous to human CIAPIN1 (cytokine induced apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 7.5), CNS E14 (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.86 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95546446..95565454, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94819818..94838830, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

anamorsin exerts a neuroprotective effect by reducing intracellular ROS levels and subsequently attenuating activated stress-activated MAP kinases pathways
Title: Anamorsin attenuates cupric chloride-induced dopaminergic neuronal cell death.
Tat-CIAPIN1 protein transduced into HT-22cells and significantly inhibited cell death, DNA fragmentation, and reactive oxygen species (ROS) generation.
Title: Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways.
Among 46 putative substrates identified in MN9D neuronal cells, we further evaluated whether caspase-3-mediated cleavage of anamorsin, a recently recognized cell death-defying factor in hematopoiesis, is a general feature of apoptosis.
Title: Anamorsin, a novel caspase-3 substrate in neurodegeneration.
AM was essential for both autonomous and extrinsic regulation of fetal liver hematopoiesis. This study provided new insight into the molecular regulation of hematopoiesis.
Title: The anti-apoptotic gene Anamorsin is essential for both autonomous and extrinsic regulation of murine fetal liver hematopoiesis.
play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins.
Title: PICOT is a molecule which binds to anamorsin.
These data suggest that PKCtheta;, PKCdelta, and p38MAPK activation lead to cell cycle retardation in AM KO MEF cells, and that AM may negatively regulate novel PKCs and p38MAPK in MEF cells.
Title: A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK.
Anamorsin is considered to be a necessary molecule for hematopoiesis that mediates antiapoptotic effects of various cytokines.
Title: Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis.
CIAPIN1 was localized in both the cytoplasm and the nucleus and was accumulated in the nucleolus. Bioinformatic prediction disclosed a putative nuclear localization signal and a putative nuclear export signal within mouse CIAPIN1.
Title: Subcellular localization of CIAPIN1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124525 (e-PCR)
- UniSTS:161347

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AU021794 (e-PCR)
- UniSTS:208314

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anamorsin

Names: fe-S cluster assembly protein DRE2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134141.4 → NP_598902.1 anamorsin

See identical proteins and their annotated locations for NP_598902.1

Status: VALIDATED

Source sequence(s)

AC129606

Consensus CDS

CCDS22549.1

UniProtKB/Swiss-Prot

Q3UJW5, Q8VC24, Q8WTY4, Q91W83

UniProtKB/TrEMBL

F7BWP1

Related

ENSMUSP00000125451.2, ENSMUST00000162538.9

Conserved Domains (2) summary

pfam05093
Location:233 → 301

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

cl17173
Location:26 → 95

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

95546446..95565454 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530560.3 → XP_006530623.1 anamorsin isoform X1

See identical proteins and their annotated locations for XP_006530623.1

UniProtKB/Swiss-Prot

Q3UJW5, Q8VC24, Q8WTY4, Q91W83

UniProtKB/TrEMBL

F7BWP1

Related

ENSMUSP00000034233.9, ENSMUST00000034233.15

Conserved Domains (2) summary

pfam05093
Location:233 → 301

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

cl17173
Location:26 → 95

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...