Plxna1 plexin A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plxna1provided by MGI
Official Full Name: plexin A1provided by MGI
Primary source: MGI:MGI:107685
See related: Ensembl:ENSMUSG00000030084 AllianceGenome:MGI:107685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NOV; Plxn1; PlexA1; mKIAA4053; 2600013D04Rik
Summary: Enables semaphorin receptor activity. Involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; nervous system development; and semaphorin-plexin signaling pathway. Acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in membrane. Part of semaphorin receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 77.1), ovary adult (RPKM 54.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 39.91 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (89293295..89339595, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (89316313..89362613, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.
Title: Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.
Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.
Title: Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.
Plexin-A1 expression in the inhibitory neurons of infralimbic cortex regulates the specificity of fear memory in male mice.
Title: Plexin-A1 expression in the inhibitory neurons of infralimbic cortex regulates the specificity of fear memory in male mice.
Resveratrol ameliorates the glucose uptake and lipid metabolism in gestational diabetes mellitus mice and insulin-resistant adipocytes via miR-23a-3p/NOV axis.
Title: Resveratrol ameliorates the glucose uptake and lipid metabolism in gestational diabetes mellitus mice and insulin-resistant adipocytes via miR-23a-3p/NOV axis.
PLXNA1 and PLXNA3 may have roles in inherited GnRH deficiency and cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons
Title: PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.
These results indicate the crucial involvement of PlexinA1 in the midline crossing of callosal axons during corpus callosum development in BALB/cAJ mice.
Title: PlexinA1 is crucial for the midline crossing of callosal axons during corpus callosum development in BALB/cAJ mice.
Sema3A and Plexin-A1 suppress the formation of supernumerary axons in cultured neurons, which depends on Rap1 GTPases.
Title: The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases.
species-dependent regulation of PlexA1 expression may have been crucial in the evolution of mammalian cortico-motoneuronal systems that improved fine motor control in higher primates.
Title: Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.
work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding.
Title: Structural Basis for Plexin Activation and Regulation.
PLXNA1 mediates the acquisition of malignant phenotypes induced by autocrine SEMA3A signaling in lung cancer cells.
Title: Plexin A1 signaling confers malignant phenotypes in lung cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables semaphorin receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching	IDA Inferred from Direct Assay more info	PubMed
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory nerve formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of semaphorin receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: plexin-A1

Names: plex 1; plexin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008881.2 → NP_032907.1 plexin-A1 precursor

See identical proteins and their annotated locations for NP_032907.1

Status: VALIDATED

Source sequence(s)

AK220460, BC138023, CF734847, CJ111942

Consensus CDS

CCDS20344.1

UniProtKB/Swiss-Prot

B2RQP7, P70206, Q5DTR0

Related

ENSMUSP00000131840.2, ENSMUST00000163139.8

Conserved Domains (7) summary

cd11271
Location:36 → 511

Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1

cd01179
Location:959 → 1044

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:862 → 958

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1046 → 1146

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:512 → 554

PSI; Plexin repeat

pfam01833
Location:1148 → 1232

TIG; IPT/TIG domain

pfam08337
Location:1316 → 1864

Plexin_cytopl; Plexin cytoplasmic RasGAP domain