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    Rbpms2 RNA binding protein with multiple splicing 2 [ Mus musculus (house mouse) ]

    Gene ID: 71973, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbpms2provided by MGI
    Official Full Name
    RNA binding protein with multiple splicing 2provided by MGI
    Primary source
    MGI:MGI:1919223
    See related
    Ensembl:ENSMUSG00000032387 AllianceGenome:MGI:1919223
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2400008B06Rik
    Summary
    Predicted to enable mRNA binding activity and protein homodimerization activity. Predicted to be involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of BMP signaling pathway; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; retina; and trigeminal ganglion. Orthologous to human RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 74.7), adrenal adult (RPKM 48.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbpms2 in Genome Data Viewer
    Location:
    9 C; 9 35.43 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65536638..65567818)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65629356..65660536)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2898 Neighboring gene STARR-seq mESC enhancer starr_24463 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene predicted pseudogene 10144 Neighboring gene STARR-seq mESC enhancer starr_24464 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65469333-65469516 Neighboring gene STARR-seq mESC enhancer starr_24467 Neighboring gene STARR-positive B cell enhancer ABC_E9768 Neighboring gene STARR-seq mESC enhancer starr_24469 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene ATP synthase subunit f, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway. Zhou C, et al. Reprod Biomed Online, 2023 Oct. PMID 37573751
    2. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
    3. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway.
      Title: Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic digestive tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smooth muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein with multiple splicing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028030.3 → NP_082306.2  RNA-binding protein with multiple splicing 2

      See identical proteins and their annotated locations for NP_082306.2

      Status: PROVISIONAL

      Source sequence(s)
      AC121979
      Consensus CDS
      CCDS23296.1
      UniProtKB/Swiss-Prot
      Q8VC52
      UniProtKB/TrEMBL
      Q9CWY6
      Related
      ENSMUSP00000057600.9, ENSMUST00000055844.10
      Conserved Domains (1) summary
      cd12683
      Location:24 → 99
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65536638..65567818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511456.4 → XP_006511519.1  RNA-binding protein with multiple splicing 2 isoform X1

      See identical proteins and their annotated locations for XP_006511519.1

      UniProtKB/Swiss-Prot
      Q8VC52
      UniProtKB/TrEMBL
      Q9CWY6
      Conserved Domains (1) summary
      cd12683
      Location:24 → 99
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

    2. XM_006511455.2 → XP_006511518.1  RNA-binding protein with multiple splicing 2 isoform X1

      See identical proteins and their annotated locations for XP_006511518.1

      UniProtKB/Swiss-Prot
      Q8VC52
      UniProtKB/TrEMBL
      Q9CWY6
      Related
      ENSMUSP00000131076.2, ENSMUST00000169003.8
      Conserved Domains (1) summary
      cd12683
      Location:24 → 99
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

    3. XM_006511457.3 → XP_006511520.1  RNA-binding protein with multiple splicing 2 isoform X1

      See identical proteins and their annotated locations for XP_006511520.1

      UniProtKB/Swiss-Prot
      Q8VC52
      UniProtKB/TrEMBL
      Q9CWY6
      Conserved Domains (1) summary
      cd12683
      Location:24 → 99
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

    4. XM_006511458.4 → XP_006511521.1  RNA-binding protein with multiple splicing 2 isoform X1

      See identical proteins and their annotated locations for XP_006511521.1

      UniProtKB/Swiss-Prot
      Q8VC52
      UniProtKB/TrEMBL
      Q9CWY6
      Conserved Domains (1) summary
      cd12683
      Location:24 → 99
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC52.1 GenPept UniProtKB/Swiss-Prot:Q8VC52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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