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    Spopl speckle-type BTB/POZ protein-like [ Mus musculus (house mouse) ]

    Gene ID: 76857, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spoplprovided by MGI
    Official Full Name
    speckle-type BTB/POZ protein-likeprovided by MGI
    Primary source
    MGI:MGI:1924107
    See related
    Ensembl:ENSMUSG00000026771 AllianceGenome:MGI:1924107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921517N04Rik; E430033K04Rik
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.2), placenta adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spopl in Genome Data Viewer
    Location:
    2 A3; 2 15.48 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (23382942..23462139, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (23507466..23572132, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 68 Neighboring gene predicted gene 13422 Neighboring gene neurexophilin 2 Neighboring gene STARR-seq mESC enhancer starr_03927 Neighboring gene predicted gene, 34769 Neighboring gene STARR-seq mESC enhancer starr_03928 Neighboring gene STARR-seq mESC enhancer starr_03929 Neighboring gene STARR-seq mESC enhancer starr_03930 Neighboring gene STARR-seq mESC enhancer starr_03931 Neighboring gene ubiquitin-conjugating enzyme E2D 3 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:23427670-23427971 Neighboring gene STARR-seq mESC enhancer starr_03932 Neighboring gene SH3 domain protein 2C, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_03933 Neighboring gene STARR-seq mESC enhancer starr_03934 Neighboring gene STARR-seq mESC enhancer starr_03935 Neighboring gene STARR-seq mESC enhancer starr_03936 Neighboring gene STARR-seq mESC enhancer starr_03937 Neighboring gene STARR-seq mESC enhancer starr_03939 Neighboring gene STARR-seq mESC enhancer starr_03940 Neighboring gene STARR-seq mESC enhancer starr_03942 Neighboring gene histamine N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern. Choo KB, et al. Gene, 2010 Jul 15. PMID 20399258
    2. Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Cai H, et al. Dev Biol, 2017 Dec 1. PMID 28412462, Free PMC Article
    3. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Zhang Q, et al. Dev Cell, 2006 Jun. PMID 16740475
    4. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Cai H, et al. Proc Natl Acad Sci U S A, 2016 Dec 20. PMID 27930311, Free PMC Article
    5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130583

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    speckle-type POZ protein-like
    Names
    HIB homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165997.1 → NP_001159469.1  speckle-type POZ protein-like isoform b

      See identical proteins and their annotated locations for NP_001159469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AK014913, BC111867, CJ128267, CK329864
      UniProtKB/Swiss-Prot
      Q2M2N2
      Conserved Domains (2) summary
      cd18343
      Location:104 → 226
      BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
      cd18519
      Location:222 → 317
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

    2. NM_001165998.1 → NP_001159470.1  speckle-type POZ protein-like isoform b

      See identical proteins and their annotated locations for NP_001159470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AK014913, BC111867, CJ128267, CK329864
      UniProtKB/Swiss-Prot
      Q2M2N2
      Conserved Domains (2) summary
      cd18343
      Location:104 → 226
      BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
      cd18519
      Location:222 → 317
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

    3. NM_029773.2 → NP_084049.2  speckle-type POZ protein-like isoform a

      See identical proteins and their annotated locations for NP_084049.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK014913, BC111867, CJ128267, CK329864
      Consensus CDS
      CCDS15730.1
      UniProtKB/Swiss-Prot
      A2AL52, Q2M2N2, Q3TSH4
      Related
      ENSMUSP00000114974.2, ENSMUST00000132484.7
      Conserved Domains (3) summary
      cd18519
      Location:297 → 392
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 166
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:179 → 301
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      23382942..23462139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498412.5 → XP_006498475.1  speckle-type POZ protein-like isoform X1

      Conserved Domains (3) summary
      cd18519
      Location:309 → 404
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:80 → 178
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:191 → 313
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_030252196.2 → XP_030108056.1  speckle-type POZ protein-like isoform X5

      Conserved Domains (2) summary
      cd18343
      Location:104 → 226
      BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
      cd18519
      Location:222 → 317
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

    3. XM_036162679.1 → XP_036018572.1  speckle-type POZ protein-like isoform X3

      Conserved Domains (3) summary
      cd18519
      Location:266 → 361
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:37 → 135
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:148 → 270
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    4. XM_036162681.1 → XP_036018574.1  speckle-type POZ protein-like isoform X5

      Conserved Domains (2) summary
      cd18343
      Location:104 → 226
      BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
      cd18519
      Location:222 → 317
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

    5. XM_036162682.1 → XP_036018575.1  speckle-type POZ protein-like isoform X5

      Conserved Domains (2) summary
      cd18343
      Location:104 → 226
      BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
      cd18519
      Location:222 → 317
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

    6. XM_036162683.1 → XP_036018576.1  speckle-type POZ protein-like isoform X5

      Conserved Domains (2) summary
      cd18343
      Location:104 → 226
      BTB_POZ_SPOPL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL)
      cd18519
      Location:222 → 317
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)

    7. XM_036162680.1 → XP_036018573.1  speckle-type POZ protein-like isoform X4

      Conserved Domains (3) summary
      cd18519
      Location:263 → 358
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:1 → 132
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:145 → 267
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    8. XM_006498414.4 → XP_006498477.1  speckle-type POZ protein-like isoform X2

      See identical proteins and their annotated locations for XP_006498477.1

      UniProtKB/Swiss-Prot
      A2AL52, Q2M2N2, Q3TSH4
      Conserved Domains (3) summary
      cd18519
      Location:297 → 392
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 166
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:179 → 301
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    9. XM_030252195.2 → XP_030108055.1  speckle-type POZ protein-like isoform X2

      UniProtKB/Swiss-Prot
      A2AL52, Q2M2N2, Q3TSH4
      Conserved Domains (3) summary
      cd18519
      Location:297 → 392
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 166
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:179 → 301
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    10. XM_006498417.5 → XP_006498480.1  speckle-type POZ protein-like isoform X6

      Conserved Domains (2) summary
      cl02446
      Location:80 → 178
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:191 → 291
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    11. XM_036162684.1 → XP_036018577.1  speckle-type POZ protein-like isoform X7

      Conserved Domains (2) summary
      cl02446
      Location:80 → 178
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:191 → 255
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RNA

    1. XR_866023.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2M2N2.3 GenPept UniProtKB/Swiss-Prot:Q2M2N2

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