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    Litafd LITAF domain containing [ Mus musculus (house mouse) ]

    Gene ID: 436336, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Litafdprovided by MGI
    Official Full Name
    LITAF domain containingprovided by MGI
    Primary source
    MGI:MGI:3643507
    See related
    Ensembl:ENSMUSG00000107252 AllianceGenome:MGI:3643507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5767; Gm43786; EG436336
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of cytokine production. Predicted to be active in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. Orthologous to human LITAFD (LITAF domain containing). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward testis adult (RPKM 70.3) See more
    Orthologs
    human all
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    Genomic context

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    See Litafd in Genome Data Viewer
    Location:
    16 A1; 16 4.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8489542..8501769)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8679919..8683905)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ferritin light chain 2 pseudogene Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene calcium regulated heat stable protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8616 Neighboring gene ubiquitin specific peptidase 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8745912-8746157 Neighboring gene STARR-seq mESC enhancer starr_40018 Neighboring gene STARR-seq mESC enhancer starr_40019 Neighboring gene predicted gene, 25805

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lITAF domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324517.2 → NP_001311446.2  lITAF domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC115005
      UniProtKB/TrEMBL
      A0A0J9YTU8
      Related
      ENSMUSP00000143858.3, ENSMUST00000201722.2
      Conserved Domains (1) summary
      cl02754
      Location:6 → 75
      zf-LITAF-like; LITAF-like zinc ribbon domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      8489542..8501769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249172.2 → XP_030105032.1  lITAF domain-containing protein isoform X2

      Conserved Domains (1) summary
      pfam10601
      Location:63 → 98
      zf-LITAF-like; LITAF-like zinc ribbon domain

    2. XM_030249171.2 → XP_030105031.1  lITAF domain-containing protein isoform X1

      Conserved Domains (1) summary
      pfam10601
      Location:63 → 131
      zf-LITAF-like; LITAF-like zinc ribbon domain

    3. XM_030249173.2 → XP_030105033.1  lITAF domain-containing protein isoform X3

      Conserved Domains (1) summary
      pfam10601
      Location:57 → 92
      zf-LITAF-like; LITAF-like zinc ribbon domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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