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    SOK1 Sok1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SOK1
    Official Full Name
    Sok1p
    Primary source
    SGD:S000002413
    Locus tag
    YDR006C
    See related
    AllianceGenome:SGD:S000002413; FungiDB:YDR006C; VEuPathDB:YDR006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein kinase A signaling. Located in nucleus. Orthologous to several human genes including TCP11X2 (t-complex 11 family, X-linked 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SOK1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (458542..461247, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative DNA-dependent ATPase RAD57 Neighboring gene RNA polymerase III-inhibiting protein MAF1 Neighboring gene phosphoribosylanthranilate isomerase TRP1 Neighboring gene transcriptional regulator GAL3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MBR1 gene from Saccharomyces cerevisiae is activated by and required for growth under sub-optimal conditions. Reisdorf P, et al. Mol Gen Genet, 1997 Jul. PMID 9267436
    2. Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene. Ward MP, et al. Mol Cell Biol, 1994 Sep. PMID 8065298, Free PMC Article
    3. Genetic suppressors of Δgrx3 Δgrx4, lacking redundant multidomain monothiol yeast glutaredoxins, rescue growth and iron homeostasis. Li G, et al. Biosci Rep, 2022 Jun 30. PMID 35593209, Free PMC Article
    4. Functional dissection of IME1 transcription using quantitative promoter-reporter screening. Kahana S, et al. Genetics, 2010 Nov. PMID 20739709, Free PMC Article
    5. Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Schmelzle T, et al. Mol Cell Biol, 2004 Jan. PMID 14673167, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP/PKA signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sok1p
    NP_010289.3
    • hypothetical protein; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      458542..461247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180314.3 → NP_010289.3  TPA: Sok1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010289.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRZ4, P40317
      UniProtKB/TrEMBL
      A6ZXX2, B3LGQ2, B5VFR5, C7GXY4, C8Z4S6, G2WCG0, N1P7Y0
      Conserved Domains (1) summary
      pfam05794
      Location:390 → 791
      Tcp11; T-complex protein 11
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40317.2

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