Robo1 roundabout guidance receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Robo1provided by MGI
Official Full Name: roundabout guidance receptor 1provided by MGI
Primary source: MGI:MGI:1274781
See related: Ensembl:ENSMUSG00000022883 AllianceGenome:MGI:1274781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DUTT1; Gm310
Summary: Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within several processes, including axon guidance; heart development; and mammary duct terminal end bud growth. Located in axolemma. Is expressed in several structures, including autopod; central nervous system; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung cancer. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus; congenital nystagmus; multiple myeloma; panhypopituitarism; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 19.0), whole brain E14.5 (RPKM 14.9) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.1; 16 41.08 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (71824406..72844379)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (72027518..73047491)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
Title: Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
Title: ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma.
Title: Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma.
ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment.
Title: ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment.
Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling.
Title: Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling.
Alveolar progenitor differentiation and lactation depends on paracrine inhibition of notch via ROBO1/CTNNB1/JAG1.
Title: Alveolar progenitor differentiation and lactation depends on paracrine inhibition of notch via ROBO1/CTNNB1/JAG1.
Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.
Title: Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.
Slit2/Robo1 Mitigates DSS-induced Ulcerative Colitis by Activating Autophagy in Intestinal Stem Cell.
Title: Slit2/Robo1 Mitigates DSS-induced Ulcerative Colitis by Activating Autophagy in Intestinal Stem Cell.
Tissue-specific angiogenic and invasive properties of human neonatal thymus and bone MSCs: Role of SLIT3-ROBO1.
Title: Tissue-specific angiogenic and invasive properties of human neonatal thymus and bone MSCs: Role of SLIT3-ROBO1.
SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling.
Title: SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136204 (e-PCR)
- UniSTS:210199

D16Mit151 (e-PCR), detects polymorphism
- UniSTS:127785

Robo1 (e-PCR), detects polymorphism
- UniSTS:498508

D16Mit187 (e-PCR), detects polymorphism
- UniSTS:127820

AW742721 (e-PCR)
- UniSTS:209236

Robo1 (e-PCR), detects polymorphism
- UniSTS:498325

D16Mit65 (e-PCR), detects polymorphism
- UniSTS:127899

AW494633 (e-PCR)
- UniSTS:180929

Y17793 (e-PCR)
- UniSTS:163577

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables LRR domain binding	ISO Inferred from Sequence Orthology more info
enables axon guidance receptor activity	IEA Inferred from Electronic Annotation more info
enables axon guidance receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Roundabout signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Roundabout signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in aorta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aortic valve morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon midline choice point recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cushion formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart induction	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary duct terminal end bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in olfactory bulb interneuron development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in outflow tract septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: roundabout homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415010.1 → NP_001401939.1 roundabout homolog 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC121890, AC124726, AC164551, CT025560

UniProtKB/TrEMBL

A0A338P6F7
NM_019413.3 → NP_062286.2 roundabout homolog 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_062286.2

Status: VALIDATED

Source sequence(s)

AC124726, AC164551

Consensus CDS

CCDS37376.1

UniProtKB/Swiss-Prot

O89026

UniProtKB/TrEMBL

G5E843

Related

ENSMUSP00000023600.8, ENSMUST00000023600.8

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:326 → 415

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:522 → 608

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:739 → 825

fn3; Fibronectin type III domain

cl11960
Location:430 → 503

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

71824406..72844379

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522960.4 → XP_006523023.1 roundabout homolog 1 isoform X5

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd05724
Location:178 → 262

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:283 → 351

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:372 → 461

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:71 → 170

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:568 → 654

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:785 → 868

fn3; Fibronectin type III domain

pfam07679
Location:462 → 549

I-set; Immunoglobulin I-set domain
XM_036159819.1 → XP_036015712.1 roundabout homolog 1 isoform X7

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd00063
Location:555 → 641

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:772 → 858

fn3; Fibronectin type III domain

cd05724
Location:164 → 249

IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05725
Location:256 → 338

IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05726
Location:346 → 443

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:59 → 157

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:450 → 536

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
XM_036159820.1 → XP_036015713.1 roundabout homolog 1 isoform X13

UniProtKB/Swiss-Prot

O89026

Conserved Domains (7) summary

cd00063
Location:527 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:744 → 830

fn3; Fibronectin type III domain

cd05724
Location:136 → 221

IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05725
Location:228 → 310

IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05726
Location:318 → 415

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:31 → 129

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:422 → 508

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
XM_006522963.5 → XP_006523026.1 roundabout homolog 1 isoform X10

UniProtKB/Swiss-Prot

O89026

Conserved Domains (7) summary

cd05724
Location:150 → 234

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:255 → 323

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:344 → 433

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:43 → 142

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:540 → 626

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:757 → 840

fn3; Fibronectin type III domain

pfam07679
Location:434 → 521

I-set; Immunoglobulin I-set domain
XM_017316894.3 → XP_017172383.1 roundabout homolog 1 isoform X4

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd05724
Location:181 → 265

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:286 → 354

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:375 → 464

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:74 → 173

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:571 → 657

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:788 → 871

fn3; Fibronectin type III domain

pfam07679
Location:465 → 552

I-set; Immunoglobulin I-set domain
XM_006522961.4 → XP_006523024.1 roundabout homolog 1 isoform X8

UniProtKB/Swiss-Prot

O89026

Conserved Domains (7) summary

cd05724
Location:153 → 237

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:258 → 326

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:347 → 436

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:46 → 145

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:543 → 629

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:760 → 843

fn3; Fibronectin type III domain

pfam07679
Location:437 → 524

I-set; Immunoglobulin I-set domain
XM_006522958.3 → XP_006523021.1 roundabout homolog 1 isoform X3

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd05724
Location:207 → 291

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:312 → 380

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:401 → 490

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:100 → 199

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:597 → 683

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:814 → 897

fn3; Fibronectin type III domain

pfam07679
Location:491 → 578

I-set; Immunoglobulin I-set domain
XM_006522964.5 → XP_006523027.1 roundabout homolog 1 isoform X12

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd05724
Location:207 → 291

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:312 → 380

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:401 → 490

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:100 → 199

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:597 → 683

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:814 → 897

fn3; Fibronectin type III domain

pfam07679
Location:491 → 578

I-set; Immunoglobulin I-set domain
XM_017316893.2 → XP_017172382.1 roundabout homolog 1 isoform X1

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd05724
Location:207 → 291

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:312 → 380

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:401 → 490

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:100 → 199

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:597 → 683

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:814 → 897

fn3; Fibronectin type III domain

pfam07679
Location:491 → 578

I-set; Immunoglobulin I-set domain
XM_006522962.5 → XP_006523025.1 roundabout homolog 1 isoform X9

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd05724
Location:207 → 291

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:312 → 380

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:401 → 490

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:100 → 199

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:597 → 683

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:814 → 897

fn3; Fibronectin type III domain

pfam07679
Location:491 → 578

I-set; Immunoglobulin I-set domain
XM_006522957.3 → XP_006523020.1 roundabout homolog 1 isoform X2

UniProtKB/TrEMBL

A0A338P6F7

Related

ENSMUSP00000155958.2, ENSMUST00000232205.2

Conserved Domains (7) summary

cd05724
Location:207 → 291

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:312 → 380

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:398 → 487

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:100 → 199

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:594 → 680

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:811 → 894

fn3; Fibronectin type III domain

pfam07679
Location:488 → 575

I-set; Immunoglobulin I-set domain
XM_030249003.2 → XP_030104863.1 roundabout homolog 1 isoform X11

UniProtKB/TrEMBL

A0A338P6F7

Conserved Domains (7) summary

cd05724
Location:207 → 291

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:312 → 380

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:398 → 487

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:100 → 199

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:594 → 680

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:811 → 894

fn3; Fibronectin type III domain

pfam07679
Location:488 → 575

I-set; Immunoglobulin I-set domain
XM_006522965.3 → XP_006523028.1 roundabout homolog 1 isoform X14

UniProtKB/Swiss-Prot

O89026

Conserved Domains (7) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:329 → 418

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:525 → 611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:742 → 825

fn3; Fibronectin type III domain

pfam07679
Location:419 → 506

I-set; Immunoglobulin I-set domain
XM_030249005.2 → XP_030104865.1 roundabout homolog 1 isoform X15

UniProtKB/Swiss-Prot

O89026

Conserved Domains (7) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:326 → 415

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:522 → 608

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:739 → 822

fn3; Fibronectin type III domain

pfam07679
Location:416 → 503

I-set; Immunoglobulin I-set domain