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    DUS4 tRNA dihydrouridine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DUS4
    Official Full Name
    tRNA dihydrouridine synthase
    Primary source
    SGD:S000004397
    Locus tag
    YLR405W
    See related
    AllianceGenome:SGD:S000004397; FungiDB:YLR405W; VEuPathDB:YLR405W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DUS4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (929789..930892)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene zinc-coordinating transcription factor SFP1 Neighboring gene seipin Neighboring gene ribosomal 60S subunit protein L31B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. Xing F, et al. J Biol Chem, 2004 Apr 23. PMID 14970222
    2. Rapid tRNA decay can result from lack of nonessential modifications. Alexandrov A, et al. Mol Cell, 2006 Jan 6. PMID 16387656
    3. Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1). Millson S, et al. Cell Stress Chaperones, 2014 Sep. PMID 24452458, Free PMC Article
    4. Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Reid RJ, et al. Genome Res, 2011 Mar. PMID 21173034, Free PMC Article
    5. Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions. León Ortiz AM, et al. DNA Repair (Amst), 2011 May 5. PMID 21459050, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA-dihydrouridine20a synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine20b synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA dihydrouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tRNA dihydrouridine synthase
    NP_013509.1
    • Dihydrouridine synthase; modifies pre-tRNAs at U20a and U20b of the D loop; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      929789..930892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182293.1 → NP_013509.1  TPA: tRNA dihydrouridine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013509.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ38, Q06063
      UniProtKB/TrEMBL
      B3RHR7, C8ZE14, N1P7C8
      Conserved Domains (1) summary
      pfam01207
      Location:45 → 361
      Dus; Dihydrouridine synthase (Dus)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06063.1

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