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    RAD61 Rad61p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RAD61
    Official Full Name
    Rad61p
    Primary source
    SGD:S000002421
    Locus tag
    YDR014W
    See related
    AllianceGenome:SGD:S000002421; FungiDB:YDR014W; VEuPathDB:YDR014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    WPL1
    Summary
    Involved in several processes, including chromatin looping; meiotic DNA double-strand break formation; and negative regulation of chromosome organization. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RAD61 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (474046..475989)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L4B Neighboring gene DNA replication protein PSF1 Neighboring gene Hed1p Neighboring gene Dad1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Budding yeast Wapl controls sister chromatid cohesion maintenance and chromosome condensation. Lopez-Serra L, et al. Curr Biol, 2013 Jan 7. PMID 23219725
    2. Rad61/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis. Challa K, et al. Nucleic Acids Res, 2016 Apr 20. PMID 26825462, Free PMC Article
    3. ROCC, a conserved region in cohesin's Mcd1 subunit, is essential for the proper regulation of the maintenance of cohesion and establishment of condensation. Eng T, et al. Mol Biol Cell, 2014 Aug 15. PMID 24966169, Free PMC Article
    4. A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase. Guacci V, et al. Mol Biol Cell, 2015 Jan 1. PMID 25378582, Free PMC Article
    5. G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in eco1/ctf7 rad61 null cells during hyperthermic stress in Saccharomyces cerevisiae. Buskirk S, et al. G3 (Bethesda), 2022 Jul 29. PMID 35736360, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The unique role of Rad61/Wapl is to promote non-crossover recombination by releasing [Pds5+Rec8]. For this effect, Rad61/Wapl probably acts to maintain homolog bias by preventing channeling into sister interactions.
      Title: Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.
    2. we confirmed that this release indeed accompanies the dissociation of acetylated Smc3 as well as Rec8 from meiotic chromosomes during late prophase-I. This release requires, in addition to PLK, the cohesin regulator, Wapl (Rad61/Wpl1 in yeast), and Dbf4-dependent Cdc7 kinase (DDK)
      Title: Meiosis-specific prophase-like pathway controls cleavage-independent release of cohesin by Wapl phosphorylation.
    3. Rad61/Wpl1 is required for efficient resolution of telomere clustering during meiosis I, indicating a positive effect of Rad61/Wpl1 on the cohesin function required for telomere dynamics.
      Title: Rad61/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis.
    4. RAD61 deletion rescues the condensation defect, but importantly, neither the temperature sensitivity nor cohesion defects exhibited by pds5-1 mutant cells.
      Title: Pds5 regulators segregate cohesion and condensation pathways in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of maintenance of mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of maintenance of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rad61p
    NP_010297.1
    • Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      474046..475989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180322.1 → NP_010297.1  TPA: Rad61p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS00, Q99359
      UniProtKB/TrEMBL
      A6ZXX9, B5VFS2, C8Z4T3, N1P615
      Conserved Domains (1) summary
      pfam16997
      Location:254 → 630
      Wap1; Wap1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99359.1

    Gene LinkOut

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