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    SPI1 Spi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPI1
    Official Full Name
    Spi1p
    Primary source
    SGD:S000000952
    Locus tag
    YER150W
    See related
    AllianceGenome:SGD:S000000952; FungiDB:YER150W; VEuPathDB:YER150W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be a structural constituent of cell wall. Involved in response to acidic pH. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPI1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (468370..468816)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene TATA-binding protein Neighboring gene Pea2p Neighboring gene tRNA-Val Neighboring gene mRNA-binding ubiquitin-specific protease UBP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin ligase Rsp5p is involved in the gene expression changes during nutrient limitation in Saccharomyces cerevisiae. Cardona F, et al. Yeast, 2009 Jan. PMID 19180642
    2. The SPI1 gene, encoding a glycosylphosphatidylinositol-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak-acid food preservatives. Simões T, et al. Appl Environ Microbiol, 2006 Nov. PMID 16980434, Free PMC Article
    3. Low external pH induces HOG1-dependent changes in the organization of the Saccharomyces cerevisiae cell wall. Kapteyn JC, et al. Mol Microbiol, 2001 Jan. PMID 11136466
    4. Phylogenetic origin and transcriptional regulation at the post-diauxic phase of SPI1, in Saccharomyces cerevisiae. Cardona F, et al. Cell Mol Biol Lett, 2012 Sep. PMID 22610976, Free PMC Article
    5. Screening for glycosylphosphatidylinositol (GPI)-dependent cell wall proteins in Saccharomyces cerevisiae. Hamada K, et al. Mol Gen Genet, 1998 Apr. PMID 9613572

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression in the post-diauxic phase of SPI1 is controlled by genes related to the PKA pathway and stress response and by genes involved in the PKC pathway
      Title: Phylogenetic origin and transcriptional regulation at the post-diauxic phase of SPI1, in Saccharomyces cerevisiae.
    2. SPI1 expression protects the yeast cell from damage caused by weak acids; results are consistent with the notion that Spi1p expression upon weak-acid stress leads to cell wall remodeling, especially for more lipophilic acids, decreasing cell wall porosity
      Title: The SPI1 gene, encoding a glycosylphosphatidylinositol-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak-acid food preservatives.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural constituent of cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spi1p
    NP_011077.1
    • GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a paralog, SED1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      468370..468816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179040.1 → NP_011077.1  TPA: Spi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM57, P40092
      UniProtKB/TrEMBL
      A6ZRA7, B3LRR3, B5VHS9, C7GQ46, C8Z7H3, N1P5D7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40092.1

    Gene LinkOut

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