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    CDC43 protein geranylgeranyltransferase type I subunit CDC43 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDC43
    Official Full Name
    protein geranylgeranyltransferase type I subunit CDC43
    Primary source
    SGD:S000003123
    Locus tag
    YGL155W
    See related
    AllianceGenome:SGD:S000003123; FungiDB:YGL155W; VEuPathDB:YGL155W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CAL1
    Summary
    Enables CAAX-protein geranylgeranyltransferase activity. Involved in protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDC43 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (214081..215211)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene carbonyl reductase (NADPH-dependent) ARI1 Neighboring gene alpha-mannosidase Neighboring gene holo-[acyl-carrier-protein] synthase Neighboring gene Pex14p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae. Trueblood CE, et al. Mol Cell Biol, 1993 Jul. PMID 8321228, Free PMC Article
    2. Active site determination of yeast geranylgeranyl protein transferase type I expressed in Escherichia coli. Kim H, et al. Eur J Biochem, 1999 Oct 1. PMID 10491163
    3. Genetic study of the role of calcium ions in the cell division cycle of Saccharomyces cerevisiae: a calcium-dependent mutant and its trifluoperazine-dependent pseudorevertants. Ohya Y, et al. Mol Gen Genet, 1984. PMID 6369073
    4. DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43. James CM, et al. Yeast, 1995 Nov. PMID 8585324
    5. CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase. Mayer ML, et al. J Biol Chem, 1992 Oct 15. PMID 1400380

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables CAAX-protein geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CAAX-protein geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAAX-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAAX-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CAAX-protein geranylgeranyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein geranylgeranyltransferase type I subunit CDC43
    NP_011360.1
    • Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      214081..215211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181020.1 → NP_011360.1  TPA: protein geranylgeranyltransferase type I subunit CDC43 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011360.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTZ6, P18898
      UniProtKB/TrEMBL
      A6ZU30, B3LHK8, C7GPQ1, G2WDV0, N1P4D8
      Conserved Domains (1) summary
      COG5029
      Location:1 → 376
      CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18898.2

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