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    OSH7 oxysterol-binding protein related protein OSH7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OSH7
    Official Full Name
    oxysterol-binding protein related protein OSH7
    Primary source
    SGD:S000001043
    Locus tag
    YHR001W
    See related
    AllianceGenome:SGD:S000001043; FungiDB:YHR001W; VEuPathDB:YHR001W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lipid binding activity and sterol transfer activity. Involved in several processes, including late endosome to vacuole transport; maintenance of cell polarity; and piecemeal microautophagy of the nucleus. Located in cortical endoplasmic reticulum. Orthologous to several human genes including OSBPL8 (oxysterol binding protein like 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OSH7 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (106055..107368)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ESCRT-0 subunit protein HSE1 Neighboring gene ribosomal 60S subunit protein L14B Neighboring gene ubiquinol--cytochrome-c reductase subunit 10 Neighboring gene coenzyme A transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A generic protocol for the purification and characterization of water-soluble complexes of affinity-tagged proteins and lipids. Maeda K, et al. Nat Protoc, 2014 Sep. PMID 25167057
    2. INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. Moser von Filseck J, et al. Science, 2015 Jul 24. PMID 26206936
    3. AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. Wang P, et al. EMBO J, 2005 Sep 7. PMID 16096648, Free PMC Article
    4. Osh6 requires Ist2 for localization to ER-PM contacts and efficient phosphatidylserine transport in budding yeast. D'Ambrosio JM, et al. J Cell Sci, 2020 Jun 4. PMID 32327560
    5. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda K, et al. Nature, 2013 Sep 12. PMID 23934110

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.
      Title: Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.
    2. Osh5-Osh7 bind cholesterol in vitro.
      Title: Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein related protein OSH7
    NP_011863.1
    • Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      106055..107368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179131.1 → NP_011863.1  TPA: oxysterol-binding protein related protein OSH7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011863.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKR7, P38755
      UniProtKB/TrEMBL
      A6ZSQ2, B3LSB8, C7GMR2, C8ZA66, N1P9K1
      Conserved Domains (1) summary
      pfam01237
      Location:53 → 393
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38755.1

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