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    INA22 Ina22p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    INA22
    Official Full Name
    Ina22p
    Primary source
    SGD:S000001463
    Locus tag
    YIR024C
    See related
    AllianceGenome:SGD:S000001463; FungiDB:YIR024C; VEuPathDB:YIR024C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial inner membrane. Part of INA complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See INA22 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (402841..403491, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene signal peptidase complex catalytic subunit SEC11 Neighboring gene Dal81p Neighboring gene Mnd2p Neighboring gene tyrosine protein phosphatase YVH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase. Lytovchenko O, et al. EMBO J, 2014 Aug 1. PMID 24942160, Free PMC Article
    2. Systematic screen for human disease genes in yeast. Steinmetz LM, et al. Nat Genet, 2002 Aug. PMID 12134146
    3. Identification of aluminium transport-related genes via genome-wide phenotypic screening of Saccharomyces cerevisiae. Tun NM, et al. Metallomics, 2014 Aug. PMID 24926745
    4. Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium. Scherz K, et al. G3 (Bethesda), 2014 Jul 9. PMID 25009170, Free PMC Article
    5. Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins. Konduri PC, et al. Cells, 2020 Mar 22. PMID 32235736, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. INAC maintains assembly intermediates of the F1 F0-ATP synthase in a primed state for the terminal assembly step-motor module formation.
      Title: INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules.
    2. INA22 and INA17 complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase.
      Title: The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of INA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of INA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ina22p
    NP_012290.1
    • F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Aim43p, ATP synthase subunits, and cytochrome bc1 complex assembly factors; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      402841..403491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179546.1 → NP_012290.1  TPA: Ina22p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012290.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVV5, P40576
      UniProtKB/TrEMBL
      B3LTI5, C7GLT2, N1P4A1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40576.1

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