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    VPS25 ESCRT-II subunit protein VPS25 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS25
    Official Full Name
    ESCRT-II subunit protein VPS25
    Primary source
    SGD:S000003863
    Locus tag
    YJR102C
    See related
    AllianceGenome:SGD:S000003863; FungiDB:YJR102C; VEuPathDB:YJR102C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPL12; VPT25
    Summary
    Enables structural molecule activity. Involved in ATP export; carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; and protein targeting to vacuole. Located in cytosol. Part of ESCRT II complex. Orthologous to human VPS25 (vacuolar protein sorting 25 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS25 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (619157..619765, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene mitochondrial 37S ribosomal protein RSM26 Neighboring gene CTP synthase URA8 Neighboring gene superoxide dismutase SOD1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic structure and evolution of the Vps25 family, a yeast ESCRT-II component. Slater R, et al. BMC Evol Biol, 2006 Aug 4. PMID 16889659, Free PMC Article
    2. Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II. Wernimont AK, et al. BMC Struct Biol, 2004 Dec 4. PMID 15579210, Free PMC Article
    3. Structure of the ESCRT-II endosomal trafficking complex. Hierro A, et al. Nature, 2004 Sep 9. PMID 15329733
    4. Cigarette smoke affects ESCRT-mediated vacuolar activity in Saccharomyces cerevisiae. Maiti A, et al. Toxicol Lett, 2021 Mar 1. PMID 33309995
    5. Structural and functional organization of the ESCRT-I trafficking complex. Kostelansky MS, et al. Cell, 2006 Apr 7. PMID 16615894, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
      Title: ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
    2. Crystal structure of full-length Vps25, composed of two homologous winged-helix domains.
      Title: Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT II complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ESCRT II complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ESCRT-II subunit protein VPS25
    NP_012636.1
    • Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      619157..619765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181760.1 → NP_012636.1  TPA: ESCRT-II subunit protein VPS25 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012636.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWS1, P47142
      UniProtKB/TrEMBL
      A6ZQ58, B3LQI7, C7GMA5, C8ZBP9, G2WHA5, N1P1Q1
      Conserved Domains (1) summary
      pfam05871
      Location:7 → 163
      ESCRT-II; ESCRT-II complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47142.1

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