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    ARG80 Arg80p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855059, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARG80
    Official Full Name
    Arg80p
    Primary source
    SGD:S000004645
    Locus tag
    YMR042W
    See related
    AllianceGenome:SGD:S000004645; FungiDB:YMR042W; VEuPathDB:YMR042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ARGR1
    Summary
    Enables cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of arginine biosynthetic process; and regulation of arginine catabolic process. Located in nucleus. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARG80 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (352603..353136)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2 Neighboring gene tRNA-Phe Neighboring gene transcription factor MCM1 Neighboring gene Ioc4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The regulation of arginine biosynthesis in Saccharomyces cerevisiae. The specificity of argR- mutations and the general control of amino-acid biosynthesis. Delforge J, et al. Eur J Biochem, 1975 Sep 1. PMID 1100402
    2. Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF. Hipskind RA, et al. Nature, 1991 Dec 19-26. PMID 1722028
    3. A protein domain conserved between yeast MCM1 and human SRF directs ternary complex formation. Mueller CG, et al. EMBO J, 1991 Dec. PMID 1756729, Free PMC Article
    4. On the nature of argR mutations is Saccharomyces cerevisiae. Hoet PP, et al. Eur J Biochem, 1974 Mar 15. PMID 4365239
    5. Characterization of two genes, ARGRI and ARGRIII required for specific regulation of arginine metabolism in yeast. Dubois E, et al. Mol Gen Genet, 1987 Apr. PMID 3298999

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of arginine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arg80p
    NP_013756.1
    • Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      352603..353136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182539.1 → NP_013756.1  TPA: Arg80p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013756.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZL7, P07249
      UniProtKB/TrEMBL
      A6ZMA4, B3LLU1, B5VPH2, C7GL77, C8ZEP9, G2WK95
      Conserved Domains (1) summary
      COG5068
      Location:1 → 177
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07249.2

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