MRS6 GTPase-activating protein MRS6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MRS6
Official Full Name: GTPase-activating protein MRS6
Primary source: SGD:S000005897
Locus tag: YOR370C
See related: AllianceGenome:SGD:S000005897; FungiDB:YOR370C; VEuPathDB:YOR370C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MSI4
Summary: Enables small GTPase binding activity. Contributes to Rab geranylgeranyltransferase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein geranylgeranylation; and protein targeting to membrane. Located in cytoplasm and membrane. Part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in asthma and choroideremia. Orthologous to human CHM (CHM Rab escort protein) and CHML (CHM like Rab escort protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MRS6 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1029183..1030994, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the essential Rab escort protein Mrs6 exhibited a nutrient-sensitive interaction with Sfp1
Title: A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis.
structural analysis of the GDP dissociation inhibitor rab membrane extraction mechanism through Rab.GDI and Rab.MRS6 complexes
Title: A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
contributes_to Rab geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to Rab geranylgeranyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables small GTPase binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein geranylgeranylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rab-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rab-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTPase-activating protein MRS6

NP_015015.1

Rab escort protein; type II geranylgeranyltransferase complex (Bet2p-Bet4p) chaperone that complexes with newly synthesized Rab GTPases, like Ypt1p and Sec4p, leading to their prenylation and membrane delivery; modulates the TOR pathway through interactions with Sfp1p; alters the kinetics of MAPK pathway activation and polarity reorganization during filamentous growth; sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1029183..1030994 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183790.1 → NP_015015.1 TPA: GTPase-activating protein MRS6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015015.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W363, P32864, Q06761

UniProtKB/TrEMBL

A6ZPJ8, C8ZHB8, N1NX31

Conserved Domains (1) summary

COG5044
Location:44 → 510

MRS6; RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]