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    Epb41l2 erythrocyte membrane protein band 4.1 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 13822, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epb41l2provided by MGI
    Official Full Name
    erythrocyte membrane protein band 4.1 like 2provided by MGI
    Primary source
    MGI:MGI:103009
    See related
    Ensembl:ENSMUSG00000019978 AllianceGenome:MGI:103009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4.1G; NBL2; Epb4.1l2; D10Ertd398e
    Summary
    Enables PH domain binding activity and spectrin binding activity. Predicted to be involved in actomyosin structure organization and positive regulation of protein localization to cell cortex. Predicted to act upstream of or within actin cytoskeleton organization and regulation of cell shape. Predicted to be located in several cellular components, including actin cytoskeleton; cell cortex; and nucleoplasm. Predicted to be part of COP9 signalosome. Predicted to be active in cytoskeleton and plasma membrane. Is expressed in several structures, including bone; central nervous system; sensory organ; thymus; and urinary system. Orthologous to human EPB41L2 (erythrocyte membrane protein band 4.1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 17.3), testis adult (RPKM 16.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Epb41l2 in Genome Data Viewer
    Location:
    10 A4; 10 12.26 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (25235680..25399413)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (25359782..25523519)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 7 Neighboring gene predicted gene, 25016 Neighboring gene STARR-seq mESC enhancer starr_26098 Neighboring gene predicted gene, 40617 Neighboring gene STARR-seq mESC enhancer starr_26101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:25123932-25124041 Neighboring gene predicted gene 29571 Neighboring gene small leucine-rich protein 1 Neighboring gene STARR-seq mESC enhancer starr_26106 Neighboring gene predicted gene, 36908

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunolocalization of membrane skeletal protein, 4.1G, in enteric glial cells in the mouse large intestine. Chen J, et al. Neurosci Lett, 2011 Jan 20. PMID 21093541
    2. Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation. Saito M, et al. Int J Mol Sci, 2022 Feb 14. PMID 35216233, Free PMC Article
    3. Influence of Aging on the Retina and Visual Motion Processing for Optokinetic Responses in Mice. Sugita Y, et al. Front Neurosci, 2020. PMID 33335469, Free PMC Article
    4. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves. Ivanovic A, et al. J Cell Biol, 2012 Feb 6. PMID 22291039, Free PMC Article
    5. Expression of protein 4.1G in Schwann cells of the peripheral nervous system. Ohno N, et al. J Neurosci Res, 2006 Aug 15. PMID 16752423

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation.
      Title: Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation.
    2. The 4.1G functions as a signal for proper formation of myelin in peripheral nervous system.
      Title: Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system.
    3. 4.1G has a role in cell adhesion, spreading, and migration in MEF cells by modulating the surface expression of beta1 integrin and subsequent downstream signal transduction
      Title: Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the β1 Integrin Pathway.
    4. The findings indicate that the Src-MPP6-4.1G protein complex in Schmidt-Lanterman incisures(SLIs) has a role in signal transduction in the peripheral nervous system(PNS).
      Title: Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS.
    5. 4.1G existed in an immunoprecipitable complex with spectrin and SERCA2.
      Title: Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.
    6. protein 4.1G contributes to the organization of the internodal axolemma by targeting and/or maintaining glial transmembrane proteins along the axoglial interface
      Title: The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.
    7. In the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the paranodes with a member of the membrane-associated guanylate kinase (MAGUK) family, membrane protein palmitoylated 6.
      Title: Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves.
    8. findings imply that 4.1G plays a role in spermatogenesis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction with NECL4 on Sertoli cells
      Title: Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility.
    9. 4.1G may have some roles in adhesion and/or signal transduction in unmylinated PNS nerve fibers
      Title: Immunolocalization of membrane skeletal protein, 4.1G, in enteric glial cells in the mouse large intestine.
    10. novel membrane skeletal protein, 4.1G, was found in germ cells, and considering its interaction with CADM family, it probably has roles in attachment of both Sertoli-germ and germ-germ cells
      Title: Involvement of a membrane skeletal protein, 4.1G, for Sertoli/germ cell interaction.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PH domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spectrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 2
    Names
    erythrocyte membrane protein band 4.1-like 2 retinal
    erythrocyte protein band 4.1 like 2
    erythrocyte protein band 4.1l2 long
    erythrocyte protein band 4.1l2 middle
    generally expressed protein 4.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199265.2 → NP_001186194.1  band 4.1-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001186194.1

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      Consensus CDS
      CCDS23754.1
      UniProtKB/Swiss-Prot
      G3X9B8, O70318
      UniProtKB/TrEMBL
      Q80UE3
      Related
      ENSMUSP00000055122.9, ENSMUST00000053748.16
      Conserved Domains (7) summary
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      cd14473
      Location:302 → 394
      FERM_B-lobe; FERM domain B-lobe
      pfam04382
      Location:613 → 656
      SAB; SAB domain
      pfam05902
      Location:876 → 978
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)
      pfam09379
      Location:215 → 278
      FERM_N; FERM N-terminal domain

    2. NM_001358751.2 → NP_001345680.1  band 4.1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      Consensus CDS
      CCDS87973.1
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3, Q80UE5
      Related
      ENSMUSP00000151685.2, ENSMUST00000218903.2
      Conserved Domains (5) summary
      PTZ00121
      Location:9 → 203
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:806 → 908
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    3. NM_001358753.2 → NP_001345682.1  band 4.1-like protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      B6ZHC5
      Conserved Domains (5) summary
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:741 → 843
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)
      cl26511
      Location:9 → 203
      Neuromodulin_N; Gap junction protein N-terminal region

    4. NM_001358754.2 → NP_001345683.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      Consensus CDS
      CCDS87972.1
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4
      Conserved Domains (5) summary
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:698 → 784
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)
      cl26511
      Location:9 → 203
      Neuromodulin_N; Gap junction protein N-terminal region

    5. NM_001358755.2 → NP_001345684.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2
      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:595 → 679
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    6. NM_001404797.1 → NP_001391726.1  band 4.1-like protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      Q80UE3

    7. NM_001404798.1 → NP_001391727.1  band 4.1-like protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3

    8. NM_001404799.1 → NP_001391728.1  band 4.1-like protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3

    9. NM_001404801.1 → NP_001391730.1  band 4.1-like protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3

    10. NM_001404802.1 → NP_001391731.1  band 4.1-like protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3

    11. NM_001404803.1 → NP_001391732.1  band 4.1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3, Q80UE5

    12. NM_001404805.1 → NP_001391734.1  band 4.1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3, Q80UE5

    13. NM_001404806.1 → NP_001391735.1  band 4.1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3, Q80UE5

    14. NM_001404807.1 → NP_001391736.1  band 4.1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3, Q80UE5

    15. NM_001404808.1 → NP_001391737.1  band 4.1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3, Q80UE5

    16. NM_001404809.1 → NP_001391738.1  band 4.1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3, Q80UE5

    17. NM_001404810.1 → NP_001391739.1  band 4.1-like protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    18. NM_001404811.1 → NP_001391740.1  band 4.1-like protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3

    19. NM_001404812.1 → NP_001391741.1  band 4.1-like protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    20. NM_001404813.1 → NP_001391742.1  band 4.1-like protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    21. NM_001404815.1 → NP_001391744.1  band 4.1-like protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    22. NM_001404816.1 → NP_001391745.1  band 4.1-like protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    23. NM_001404818.1 → NP_001391747.1  band 4.1-like protein 2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    24. NM_001404819.1 → NP_001391748.1  band 4.1-like protein 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    25. NM_001404828.1 → NP_001391757.1  band 4.1-like protein 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    26. NM_001404829.1 → NP_001391758.1  band 4.1-like protein 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    27. NM_001404830.1 → NP_001391759.1  band 4.1-like protein 2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    28. NM_001404831.1 → NP_001391760.1  band 4.1-like protein 2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    29. NM_001404832.1 → NP_001391761.1  band 4.1-like protein 2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    30. NM_001404833.1 → NP_001391762.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4

    31. NM_001404834.1 → NP_001391763.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4

    32. NM_001404835.1 → NP_001391764.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4
      Related
      ENSMUSP00000151875.2, ENSMUST00000217929.2

    33. NM_001404837.1 → NP_001391766.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4

    34. NM_001404838.1 → NP_001391767.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4

    35. NM_001404839.1 → NP_001391768.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4

    36. NM_001404840.1 → NP_001391769.1  band 4.1-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5, Q80UE4

    37. NM_001404841.1 → NP_001391770.1  band 4.1-like protein 2 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6

    38. NM_001404842.1 → NP_001391771.1  band 4.1-like protein 2 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC5

    39. NM_001404843.1 → NP_001391772.1  band 4.1-like protein 2 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      B6ZHC6

    40. NM_001404844.1 → NP_001391773.1  band 4.1-like protein 2 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6

    41. NM_001404845.1 → NP_001391774.1  band 4.1-like protein 2 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6

    42. NM_001404846.1 → NP_001391775.1  band 4.1-like protein 2 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6

    43. NM_001404847.1 → NP_001391776.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2

    44. NM_001404848.1 → NP_001391777.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2

    45. NM_001404849.1 → NP_001391778.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2

    46. NM_001404850.1 → NP_001391779.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2

    47. NM_001404851.1 → NP_001391780.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2

    48. NM_001404852.1 → NP_001391781.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2

    49. NM_001404853.1 → NP_001391782.1  band 4.1-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6, Q811B2

    50. NM_001404854.1 → NP_001391783.1  band 4.1-like protein 2 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC153550, AC156274
      UniProtKB/TrEMBL
      B6ZHC6

    51. NM_001404855.1 → NP_001391784.1  band 4.1-like protein 2 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      UniProtKB/TrEMBL
      B6ZHC6

    52. NM_013511.4 → NP_038539.2  band 4.1-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_038539.2

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274
      Consensus CDS
      CCDS23754.1
      UniProtKB/Swiss-Prot
      G3X9B8, O70318
      UniProtKB/TrEMBL
      Q80UE3
      Related
      ENSMUSP00000090314.7, ENSMUST00000092645.7
      Conserved Domains (7) summary
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      cd14473
      Location:302 → 394
      FERM_B-lobe; FERM domain B-lobe
      pfam04382
      Location:613 → 656
      SAB; SAB domain
      pfam05902
      Location:876 → 978
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)
      pfam09379
      Location:215 → 278
      FERM_N; FERM N-terminal domain

    RNA

    1. NR_175869.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274

    2. NR_175870.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274

    3. NR_175871.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274

    4. NR_175872.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153547, AC156274

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      25235680..25399413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512506.2 → XP_006512569.1  band 4.1-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006512569.1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    2. XM_036155581.1 → XP_036011474.1  band 4.1-like protein 2 isoform X3

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1019
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    3. XM_006512513.2 → XP_006512576.1  band 4.1-like protein 2 isoform X7

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:614 → 656
      SAB; SAB domain
      pfam05902
      Location:867 → 969
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    4. XM_006512514.2 → XP_006512577.1  band 4.1-like protein 2 isoform X9

      UniProtKB/TrEMBL
      B6ZHC5
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:614 → 656
      SAB; SAB domain
      pfam05902
      Location:842 → 928
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    5. XM_006512510.2 → XP_006512573.1  band 4.1-like protein 2 isoform X2

      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3
      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:594 → 635
      SAB; SAB domain
      pfam05902
      Location:929 → 1031
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    6. XM_030244873.1 → XP_030100733.1  band 4.1-like protein 2 isoform X6

      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3
      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:594 → 635
      SAB; SAB domain
      pfam05902
      Location:873 → 975
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    7. XM_036155582.1 → XP_036011475.1  band 4.1-like protein 2 isoform X8

      UniProtKB/TrEMBL
      Q3UNQ6, Q80UE3
      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:594 → 632
      SAB; SAB domain
      pfam05902
      Location:855 → 957
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    8. XM_006512512.2 → XP_006512575.1  band 4.1-like protein 2 isoform X5

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:880 → 982
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    9. XM_036155587.1 → XP_036011480.1  band 4.1-like protein 2 isoform X16

      UniProtKB/TrEMBL
      B6ZHC5
      Conserved Domains (5) summary
      PTZ00121
      Location:9 → 203
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:716 → 802
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    10. XM_006512517.2 → XP_006512580.1  band 4.1-like protein 2 isoform X15

      UniProtKB/TrEMBL
      B6ZHC5
      Conserved Domains (5) summary
      PTZ00121
      Location:9 → 203
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:723 → 825
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    11. XM_036155579.1 → XP_036011472.1  band 4.1-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    12. XM_036155580.1 → XP_036011473.1  band 4.1-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    13. XM_006512507.5 → XP_006512570.1  band 4.1-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006512570.1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    14. XM_006512509.5 → XP_006512572.1  band 4.1-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006512572.1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    15. XM_036155578.1 → XP_036011471.1  band 4.1-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    16. XM_036155577.1 → XP_036011470.1  band 4.1-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    17. XM_006512508.1 → XP_006512571.1  band 4.1-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006512571.1

      UniProtKB/TrEMBL
      Q80UE3
      Conserved Domains (7) summary
      PTZ00121
      Location:4 → 209
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:213 → 402
      B41; Band 4.1 homologues
      PHA03247
      Location:642 → 745
      PHA03247; large tegument protein UL36; Provisional
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:613 → 653
      SAB; SAB domain
      pfam05902
      Location:950 → 1052
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    RNA

    1. XR_001779454.2 RNA Sequence

    2. XR_004936095.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70318.2 GenPept UniProtKB/Swiss-Prot:O70318

    Gene LinkOut

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