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    Trdn triadin [ Mus musculus (house mouse) ]

    Gene ID: 76757, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trdnprovided by MGI
    Official Full Name
    triadinprovided by MGI
    Primary source
    MGI:MGI:1924007
    See related
    Ensembl:ENSMUSG00000019787 AllianceGenome:MGI:1924007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TDN; EG432451; 2310045H21Rik
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Involved in heart contraction. Acts upstream of or within establishment of localization in cell; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and response to bacterium. Predicted to be located in cytosol; nucleoplasm; and sarcoplasmic reticulum. Predicted to be part of calcium channel complex and junctional membrane complex. Predicted to be active in junctional sarcoplasmic reticulum membrane and plasma membrane. Is expressed in embryo and heart. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia and catecholaminergic polymorphic ventricular tachycardia 5. Orthologous to human TRDN (triadin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 10.6), mammary gland adult (RPKM 3.0) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Trdn in Genome Data Viewer
    Location:
    10 A4; 10 18.37 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (32959479..33352705)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (33083483..33476709)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Na+/K+ transporting ATPase interacting 2 Neighboring gene STARR-seq mESC enhancer starr_26223 Neighboring gene STARR-seq mESC enhancer starr_26224 Neighboring gene STARR-seq mESC enhancer starr_26225 Neighboring gene Braf transforming gene pseudogene Neighboring gene STARR-seq mESC enhancer starr_26226 Neighboring gene STARR-seq mESC enhancer starr_26227 Neighboring gene Smad nuclear interacting protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26228 Neighboring gene STARR-seq mESC enhancer starr_26229 Neighboring gene STARR-seq mESC enhancer starr_26230 Neighboring gene STARR-seq mESC enhancer starr_26231 Neighboring gene STARR-seq mESC enhancer starr_26233 Neighboring gene STARR-seq mESC enhancer starr_26234 Neighboring gene STARR-seq mESC enhancer starr_26235 Neighboring gene STARR-seq mESC enhancer starr_26236 Neighboring gene STARR-seq mESC enhancer starr_26237 Neighboring gene STARR-seq mESC enhancer starr_26238 Neighboring gene STARR-seq mESC enhancer starr_26239 Neighboring gene RIKEN cDNA D830005E20 gene Neighboring gene STARR-seq mESC enhancer starr_26243 Neighboring gene STARR-seq mESC enhancer starr_26245 Neighboring gene STARR-seq mESC enhancer starr_26246 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26247 Neighboring gene STARR-seq mESC enhancer starr_26248 Neighboring gene lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog Neighboring gene predicted gene, 20304 Neighboring gene STARR-seq mESC enhancer starr_26250 Neighboring gene clavesin 2 Neighboring gene STARR-seq mESC enhancer starr_26251 Neighboring gene STARR-seq mESC enhancer starr_26252 Neighboring gene predicted gene 15939 Neighboring gene sulfotransferase family 3A, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of junctional membrane complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in junctional sarcoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in junctional sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    triadin
    Names
    cardiac triadin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364696.1NP_001351625.1  triadin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153965, AC157017
      Consensus CDS
      CCDS87986.1
      UniProtKB/TrEMBL
      A0A1W2P8G7
      Related
      ENSMUSP00000152042.2, ENSMUST00000219982.2
      Conserved Domains (1) summary
      pfam05279
      Location:5073
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    2. NM_001364697.1NP_001351626.1  triadin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153965, AC157017
      Consensus CDS
      CCDS87985.1
      UniProtKB/TrEMBL
      A0A1W2P8G7
      Related
      ENSMUSP00000151583.2, ENSMUST00000217779.2
      Conserved Domains (1) summary
      pfam05279
      Location:5073
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    3. NM_029726.2NP_084002.2  triadin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109214, AC153966, AC157017, AI642378, AK009816, AK036470, BB658668
      Consensus CDS
      CCDS48532.1
      UniProtKB/Swiss-Prot
      E9Q9K5, Q8VIN7, Q8VIN8, Q8VIN9, Q9CV36
      Related
      ENSMUSP00000093436.5, ENSMUST00000095762.5
      Conserved Domains (2) summary
      PTZ00121
      Location:383646
      PTZ00121; MAEBL; Provisional
      pfam05279
      Location:4574
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      32959479..33352705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)