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    Rsph4a radial spoke head 4 homolog A (Chlamydomonas) [ Mus musculus (house mouse) ]

    Gene ID: 212892, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rsph4aprovided by MGI
    Official Full Name
    radial spoke head 4 homolog A (Chlamydomonas)provided by MGI
    Primary source
    MGI:MGI:3027894
    See related
    Ensembl:ENSMUSG00000039552 AllianceGenome:MGI:3027894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rshl3; A230081C05
    Summary
    Involved in radial spoke assembly. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and maintenance of ciliary planar beating movement pattern. Located in 9+2 motile cilium and axoneme. Part of radial spoke head 1; radial spoke head 2; and radial spoke head 3. Is expressed in lateral ventricle choroid plexus; lung epithelium; metencephalon part of 4th ventricle choroid plexus; and nasal cavity respiratory epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to human RSPH4A (radial spoke head component 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 1.0), bladder adult (RPKM 0.7) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Rsph4a in Genome Data Viewer
    Location:
    10 B1; 10 18.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (33781107..33792017)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (33905111..33916021)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26255 Neighboring gene sulfotransferase family 3A, member 1 Neighboring gene STARR-seq mESC enhancer starr_26256 Neighboring gene STARR-seq mESC enhancer starr_26257 Neighboring gene STARR-seq mESC enhancer starr_26258 Neighboring gene zinc finger containing ubiquitin peptidase 1 Neighboring gene predicted gene, 48018 Neighboring gene STARR-seq mESC enhancer starr_26259 Neighboring gene STARR-seq mESC enhancer starr_26260 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in 9+2 motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of radial spoke ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of radial spoke head IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of radial spoke head IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of radial spoke head 1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of radial spoke head 2 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of radial spoke head 3 IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    radial spoke head protein 4 homolog A
    Names
    radial spoke head-like protein 3
    radial spokehead-like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162957.1NP_001156429.1  radial spoke head protein 4 homolog A

      See identical proteins and their annotated locations for NP_001156429.1

      Status: VALIDATED

      Source sequence(s)
      AC153961
      Consensus CDS
      CCDS48534.1
      UniProtKB/Swiss-Prot
      B2RQN0, Q8BYM7
      Related
      ENSMUSP00000131647.2, ENSMUST00000169670.8
      Conserved Domains (1) summary
      pfam04712
      Location:209695
      Radial_spoke; Radial spokehead-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      33781107..33792017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)