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    Calhm6 calcium homeostasis modulator family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 215900, updated on 9-Dec-2024

    Summary

    Official Symbol
    Calhm6provided by MGI
    Official Full Name
    calcium homeostasis modulator family member 6provided by MGI
    Primary source
    MGI:MGI:2443082
    See related
    Ensembl:ENSMUSG00000046031 AllianceGenome:MGI:2443082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    INAM; Fam26f; A630077B13Rik
    Summary
    Enables voltage-gated channel activity. Involved in ATP export and regulation of natural killer cell cytokine production. Located in immunological synapse. Is expressed in ductus deferens and testis. Orthologous to human CALHM6 (calcium homeostasis modulator family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 16.2), mammary gland adult (RPKM 7.5) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Calhm6 in Genome Data Viewer
    Location:
    10 B1; 10 18.85 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (34002063..34003968, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (34126067..34127972, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 3 like Neighboring gene calcium homeostasis modulator family member 4 Neighboring gene STARR-seq mESC enhancer starr_26263 Neighboring gene calcium homeostasis modulator family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E11433 Neighboring gene dermatan sulfate epimerase Neighboring gene predicted gene, 18346

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of natural killer cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    calcium homeostasis modulator protein 6
    Names
    IFN regulatory factor 3-dependent NK-activating molecule
    family with sequence similarity 26, member F
    protein FAM26F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175449.4NP_780658.2  calcium homeostasis modulator protein 6

      See identical proteins and their annotated locations for NP_780658.2

      Status: VALIDATED

      Source sequence(s)
      AI450214, AK042270
      Consensus CDS
      CCDS23775.1
      UniProtKB/Swiss-Prot
      Q8C9E8
      Related
      ENSMUSP00000051575.7, ENSMUST00000062784.8
      Conserved Domains (1) summary
      pfam14798
      Location:4244
      Ca_hom_mod; Calcium homeostasis modulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      34002063..34003968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)