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    Cnn3 calponin 3, acidic [ Mus musculus (house mouse) ]

    Gene ID: 71994, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnn3provided by MGI
    Official Full Name
    calponin 3, acidicprovided by MGI
    Primary source
    MGI:MGI:1919244
    See related
    Ensembl:ENSMUSG00000053931 AllianceGenome:MGI:1919244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Calpo3; 1600014M03Rik
    Summary
    Predicted to enable actin filament binding activity and microtubule binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytosol; dendritic spine; and neuronal cell body. Predicted to be active in actin cytoskeleton; glutamatergic synapse; and postsynapse. Is expressed in several structures, including body cavity or lining; dentate gyrus subgranular zone; genitourinary system; respiratory system; and vertebral axis musculature. Orthologous to human CNN3 (calponin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 221.9), ovary adult (RPKM 202.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnn3 in Genome Data Viewer
    Location:
    3 G1; 3 52.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (121220190..121251854)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121426541..121458205)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08839 Neighboring gene predicted gene, 33363 Neighboring gene STARR-seq mESC enhancer starr_08840 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1234.1 Neighboring gene predicted gene, 40134 Neighboring gene STARR-seq mESC enhancer starr_08841 Neighboring gene STARR-seq mESC enhancer starr_08842 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121129235-121129536 Neighboring gene solute carrier family 44, member 3 Neighboring gene RIKEN cDNA A530020G20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:121238792-121239093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121250785-121250968 Neighboring gene STARR-seq mESC enhancer starr_08854 Neighboring gene STARR-seq mESC enhancer starr_08855 Neighboring gene predicted gene, 33547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rock-dependent calponin 3 phosphorylation regulates myoblast fusion. Shibukawa Y, et al. Exp Cell Res, 2013 Mar 10. PMID 23276748
    2. Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion. Shibukawa Y, et al. Mol Biol Cell, 2010 Nov 15. PMID 20861310, Free PMC Article
    3. A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development. Flemming A, et al. PLoS One, 2015. PMID 26046660, Free PMC Article
    4. Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. Maddala R, et al. Sci Rep, 2020 Jan 28. PMID 31992794, Free PMC Article
    5. Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties. Junghans D, et al. FEBS J, 2018 Jan. PMID 29151265

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results reveal that CNN3 plays a crucial role in regulating lens epithelial contractile activity and provide supporting evidence that CNN-3 deficiency is associated with the induction of epithelial plasticity, fibrogenic activity and mechanosensitive Yap/Taz (Wwtr1) transcriptional activation.
      Title: Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants.
    2. provides evidence for an important role of Cnn3 during development of the embryonic brain and in regulating NSC function
      Title: Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.
    3. h3/acidic calponin controls fibroblast migration by regulation of ERK1/2-mediated l-caldesmon phosphorylation.
      Title: h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calponin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028044.2 → NP_082320.1  calponin-3

      See identical proteins and their annotated locations for NP_082320.1

      Status: PROVISIONAL

      Source sequence(s)
      AK005460
      Consensus CDS
      CCDS17802.1
      UniProtKB/Swiss-Prot
      Q3TW23, Q9DAW9
      UniProtKB/TrEMBL
      A0A0G2JDV8
      Related
      ENSMUSP00000029773.9, ENSMUST00000029773.13
      Conserved Domains (2) summary
      cd00014
      Location:28 → 125
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:164 → 187
      Calponin; Calponin family repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      121220190..121251854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAW9.1 GenPept UniProtKB/Swiss-Prot:Q9DAW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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