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    Sult1b1 sulfotransferase family 1B, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 56362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sult1b1provided by MGI
    Official Full Name
    sulfotransferase family 1B, member 1provided by MGI
    Primary source
    MGI:MGI:2136282
    See related
    Ensembl:ENSMUSG00000029269 AllianceGenome:MGI:2136282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ST1B1; St2b2
    Summary
    Enables aryl sulfotransferase activity. Involved in sulfation and thyroid hormone metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SULT1B1 (sulfotransferase family 1B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 7.1), colon adult (RPKM 1.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sult1b1 in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87661186..87686054, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87513327..87538195, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B38 Neighboring gene STARR-seq mESC enhancer starr_13559 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A1 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A2 Neighboring gene STARR-seq mESC enhancer starr_13560 Neighboring gene sulfotransferase family 1D, member 1 Neighboring gene sulfotransferase family 1E, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a skin cholesterol sulfotransferase, St2b2, is a trigger of epidermal cell differentiation. Shimada M, et al. Xenobiotica, 2008 Dec. PMID 18979284
    2. Involvement of ST1B subfamily of cytosolic sulfotransferase in kynurenine metabolism to form natriuretic xanthurenic acid sulfate. Senggunprai L, et al. J Pharmacol Exp Ther, 2008 Dec. PMID 18815351
    3. Molecular cloning, expression, and characterization of a novel mouse liver SULT1B1 sulfotransferase. Saeki Y, et al. J Biochem, 1998 Jul. PMID 9644246
    4. Expression of novel podocyte-associated proteins sult1b1 and ankrd25. Xu X, et al. Nephron Exp Nephrol, 2011. PMID 20720434
    5. Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog. Tsoi C, et al. Arch Biochem Biophys, 2001 Jun 1. PMID 11368519

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes.
      Title: Expression of novel podocyte-associated proteins sult1b1 and ankrd25.
    2. mSult1b1 is suggested as a major enzyme responsible for XA sulfation in jejunum
      Title: Involvement of ST1B subfamily of cytosolic sulfotransferase in kynurenine metabolism to form natriuretic xanthurenic acid sulfate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aryl sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ethanol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ethanol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flavonoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flavonoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phenol-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfotransferase 1B1
    Names
    dopa/tyrosine sulfotransferase
    sulfotransferase family cytosolic 1B member 1
    NP_001343872.1
    NP_001369766.1
    NP_063931.1
    XP_006535215.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356943.1 → NP_001343872.1  sulfotransferase 1B1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC158917, AK087595
      Consensus CDS
      CCDS19391.1
      UniProtKB/Swiss-Prot
      Q8C301, Q9QWG7, Q9Z2T0
      Related
      ENSMUSP00000112679.2, ENSMUST00000117455.8
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 289
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001382837.1 → NP_001369766.1  sulfotransferase 1B1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC158917
      UniProtKB/Swiss-Prot
      Q8C301, Q9QWG7, Q9Z2T0
      Related
      ENSMUSP00000112844.2, ENSMUST00000120150.2
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 289
      Sulfotransfer_1; Sulfotransferase domain

    3. NM_019878.4 → NP_063931.1  sulfotransferase 1B1

      See identical proteins and their annotated locations for NP_063931.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC158917
      Consensus CDS
      CCDS19391.1
      UniProtKB/Swiss-Prot
      Q8C301, Q9QWG7, Q9Z2T0
      Related
      ENSMUSP00000031199.5, ENSMUST00000031199.11
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 289
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      87661186..87686054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535152.4 → XP_006535215.1  sulfotransferase 1B1 isoform X1

      See identical proteins and their annotated locations for XP_006535215.1

      UniProtKB/Swiss-Prot
      Q8C301, Q9QWG7, Q9Z2T0
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 289
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWG7.2 GenPept UniProtKB/Swiss-Prot:Q9QWG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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