Dennd5b DENN domain containing 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dennd5bprovided by MGI
Official Full Name: DENN domain containing 5Bprovided by MGI
Primary source: MGI:MGI:2444273
See related: Ensembl:ENSMUSG00000030313 AllianceGenome:MGI:2444273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm17524; 9330160C06Rik; D030011O10Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of triglyceride transport. Predicted to be located in membrane. Orthologous to human DENND5B (DENN domain containing 5B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 4.7), cerebellum adult (RPKM 4.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 78.71 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (148889566..149003178, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (148988069..149101680, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis.
Title: Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis.
DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass.
Title: DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

AI852444 (e-PCR)
- UniSTS:164344

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of triglyceride transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DENN domain-containing protein 5B

Names: DENN/MADD domain containing 5B; RAB6IP1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177192.3 → NP_796166.2 DENN domain-containing protein 5B

See identical proteins and their annotated locations for NP_796166.2

Status: VALIDATED

Source sequence(s)

AC140327, AK135015, BB656426, BC132535, CN537548, CV558497

Consensus CDS

CCDS20714.2

UniProtKB/Swiss-Prot

A2RSQ0, Q8BII7, Q8BWK2

Related

ENSMUSP00000107182.2, ENSMUST00000111557.8

Conserved Domains (6) summary

smart00801
Location:499 → 574

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:19 → 120

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:936 → 1044

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:187 → 375

DENN; DENN (AEX-3) domain

pfam02759
Location:780 → 924

RUN; RUN domain

cl02689
Location:1127 → 1264

RUN; RUN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

148889566..149003178 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507063.5 → XP_006507126.1 DENN domain-containing protein 5B isoform X1

Conserved Domains (6) summary

smart00801
Location:521 → 596

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:19 → 142

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:958 → 1066

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:209 → 397

DENN; DENN (AEX-3) domain

pfam02759
Location:802 → 946

RUN; RUN domain

cl02689
Location:1149 → 1286

RUN; RUN domain
XM_017321643.2 → XP_017177132.1 DENN domain-containing protein 5B isoform X2

Conserved Domains (6) summary

smart00801
Location:421 → 496

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:1 → 42

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:858 → 966

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:109 → 297

DENN; DENN (AEX-3) domain

pfam02759
Location:702 → 846

RUN; RUN domain

cl02689
Location:1049 → 1186

RUN; RUN domain
XM_036166229.1 → XP_036022122.1 DENN domain-containing protein 5B isoform X3

Conserved Domains (5) summary

smart00801
Location:193 → 268

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:630 → 738

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02759
Location:474 → 618

RUN; RUN domain

cl02689
Location:821 → 958

RUN; RUN domain

cl11519
Location:1 → 69

DENN; DENN (AEX-3) domain
XM_030255459.2 → XP_030111319.1 DENN domain-containing protein 5B isoform X3

Conserved Domains (5) summary

smart00801
Location:193 → 268

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:630 → 738

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02759
Location:474 → 618

RUN; RUN domain

cl02689
Location:821 → 958

RUN; RUN domain

cl11519
Location:1 → 69

DENN; DENN (AEX-3) domain
XM_036166230.1 → XP_036022123.1 DENN domain-containing protein 5B isoform X4

Conserved Domains (4) summary

smart00801
Location:77 → 152

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:514 → 622

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02759
Location:358 → 502

RUN; RUN domain

cl02689
Location:705 → 842

RUN; RUN domain