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    Mrgprd MAS-related GPR, member D [ Mus musculus (house mouse) ]

    Gene ID: 211578, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Mrgprdprovided by MGI
    Official Full Name
    MAS-related GPR, member Dprovided by MGI
    Primary source
    MGI:MGI:3033142
    See related
    Ensembl:ENSMUSG00000051207 AllianceGenome:MGI:3033142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mgrd; MrgD; TGR7; Gm499
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in genitourinary system; nervous system; and skin. Used to study dilated cardiomyopathy. Orthologous to human MRGPRD (MAS related GPR family member D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Mrgprd in Genome Data Viewer
    Location:
    7 F5; 7 89.06 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144868572..144877796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (145314835..145324059)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene two pore segment channel 2 Neighboring gene VISTA enhancer mm1497 Neighboring gene small integral membrane protein 38 Neighboring gene STARR-seq mESC enhancer starr_20570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:152429156-152429339 Neighboring gene STARR-positive B cell enhancer ABC_E3765 Neighboring gene STARR-seq mESC enhancer starr_20571 Neighboring gene MAS-related GPR, member F Neighboring gene STARR-seq mESC enhancer starr_20573

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mechanisms of itch evoked by β-alanine. Liu Q, et al. J Neurosci, 2012 Oct 17. PMID 23077038, Free PMC Article
    2. Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors. Dussor G, et al. J Neurophysiol, 2008 Apr. PMID 18234974, Free PMC Article
    3. Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons. Wang H, et al. J Neurosci, 2009 Oct 21. PMID 19846708, Free PMC Article
    4. Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism. Cerri GC, et al. J Nutr Biochem, 2023 Apr. PMID 36641071
    5. Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice. Oliveira AC, et al. Am J Physiol Heart Circ Physiol, 2019 Jan 1. PMID 30339496

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Accumulation of beta-aminoisobutyric acid mediates hyperalgesia in ovariectomized mice through Mas-related G protein-coupled receptor D signaling.
      Title: Accumulation of β-aminoisobutyric acid mediates hyperalgesia in ovariectomized mice through Mas-related G protein-coupled receptor D signaling.
    2. The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy.
      Title: The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy.
    3. Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
      Title: Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
    4. Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
      Title: Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
    5. Identification of MrgprD expression in mouse enteric neurons.
      Title: Identification of MrgprD expression in mouse enteric neurons.
    6. Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-kappaB activation through interaction with TAK1 and IKK complex.
      Title: Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex.
    7. Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
      Title: Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
    8. This study shows, for the first time, the expression and localization of MrgprD in the intestinal tract and in macrophages and T lymphocytes, indicating the potential roles of MrgprD in intestinal mobility and immunity.
      Title: Expression and localization of MrgprD in mouse intestinal tract.
    9. MrgD-deficient mice presented a pronounced dilated cardiomyopathy with a marked decrease in systolic function.
      Title: Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice.
    10. MrgprD is essential in cold allodynia in CCI-induced neuropathic pain through the PKA-TRP-A1 pathway
      Title: Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (9)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member D
    Names
    G protein-coupled receptor MrgD
    G-protein coupled receptor TGR7
    Mas-related G protein-coupled receptor d
    beta-alanine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203490.4 → NP_987075.1  mas-related G-protein coupled receptor member D

      See identical proteins and their annotated locations for NP_987075.1

      Status: VALIDATED

      Source sequence(s)
      AC132081, AC225443
      Consensus CDS
      CCDS22057.1
      UniProtKB/Swiss-Prot
      Q91ZB8
      UniProtKB/TrEMBL
      Q5UCB4
      Related
      ENSMUSP00000063021.7, ENSMUST00000062163.8
      Conserved Domains (2) summary
      pfam00001
      Location:43 → 278
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:36 → 220
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      144868572..144877796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZB8.1 GenPept UniProtKB/Swiss-Prot:Q91ZB8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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