Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chrna10provided by MGI
Official Full Name: cholinergic receptor, nicotinic, alpha polypeptide 10provided by MGI
Primary source: MGI:MGI:3609260
See related: Ensembl:ENSMUSG00000066279 AllianceGenome:MGI:3609260
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within cholinergic synaptic transmission; detection of mechanical stimulus involved in sensory perception of sound; and inner ear morphogenesis. Predicted to be located in axon and perikaryon. Predicted to be part of transmembrane transporter complex. Predicted to be active in cholinergic synapse; neuron projection; and postsynaptic specialization membrane. Orthologous to human CHRNA10 (cholinergic receptor nicotinic alpha 10 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 2.5), heart adult (RPKM 1.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.71 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101760469..101766564, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102111260..102116971, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.
Title: Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.
Efferent feedback controls bilateral auditory spontaneous activity.
Title: Efferent feedback controls bilateral auditory spontaneous activity.
Characterization of HA-tagged alpha9 and alpha10 nAChRs in the mouse cochlea.
Title: Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea.
Attenuation in Nicotinic Acetylcholine Receptor alpha9 and alpha10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
Title: Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
we developed RgIA4, a peptide that exhibits high potency for both human and rodent a9a10 nAChRs, and was at least 1,000-fold more selective for a9a10 nAChRs vs. all other molecular targets tested, including opioid and GABAB receptors
Title: Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.
Multiple features of the efferent postsynaptic complex to inner hair cells, in addition to the alpha9alpha10 nicotinic cholinergic receptors, are down-regulated in synchrony after the onset of hearing, leading to lack of responses to acetylcholine.
Title: Constitutive expression of the alpha10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing.
Co-expression of the alpha10 subunit converts the normally weak acetylcholine-mediated activity of alpha9 to a more robustly active channel with identical physiological characteristics of the native mammalian outer hair cell cholinergic receptor.
Title: alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells.
Results demonstrate that alpha9(-/-) and alpha10(-/-) mice have overlapping but nonidentical phenotypes.
Title: The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Art1 (e-PCR), detects polymorphism
- UniSTS:141124

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit alpha-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081424.1 → NP_001074893.1 neuronal acetylcholine receptor subunit alpha-10 precursor

See identical proteins and their annotated locations for NP_001074893.1

Status: PROVISIONAL

Source sequence(s)

AC118592, AC132297

Consensus CDS

CCDS40047.1

UniProtKB/TrEMBL

B2RX82

Related

ENSMUSP00000081891.2, ENSMUST00000084830.2

Conserved Domains (3) summary

cd19051
Location:239 → 324

LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC

cl28912
Location:30 → 236

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

pfam02932
Location:243 → 437

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

101760469..101766564 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508009.4 → XP_006508072.1 neuronal acetylcholine receptor subunit alpha-10 isoform X1

See identical proteins and their annotated locations for XP_006508072.1

UniProtKB/TrEMBL

B2RX82

Conserved Domains (3) summary

cd19051
Location:239 → 324

LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC

cl28912
Location:30 → 236

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

pfam02932
Location:243 → 437

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
XM_006508008.5 → XP_006508071.1 neuronal acetylcholine receptor subunit alpha-10 isoform X1

See identical proteins and their annotated locations for XP_006508071.1

UniProtKB/TrEMBL

B2RX82

Conserved Domains (3) summary

cd19051
Location:239 → 324

LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC

cl28912
Location:30 → 236

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

pfam02932
Location:243 → 437

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region