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    Cdkl5 cyclin dependent kinase like 5 [ Mus musculus (house mouse) ]

    Gene ID: 382253, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdkl5provided by MGI
    Official Full Name
    cyclin dependent kinase like 5provided by MGI
    Primary source
    MGI:MGI:1278336
    See related
    Ensembl:ENSMUSG00000031292 AllianceGenome:MGI:1278336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stk9
    Summary
    Predicted to enable ATP binding activity; protein kinase activity; and small GTPase binding activity. Acts upstream of or within protein localization to nucleus. Predicted to be located in several cellular components, including ciliary tip; microtubule organizing center; and ruffle membrane. Predicted to be active in several cellular components, including dendrite cytoplasm; glutamatergic synapse; and postsynaptic density, intracellular component. Is expressed in several structures, including brain; genitourinary system; liver; muscle tissue; and spleen. Used to study developmental and epileptic encephalopathy 2. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 5.5), frontal lobe adult (RPKM 4.3) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Cdkl5 in Genome Data Viewer
    Location:
    X F4; X 73.95 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (159567241..159777673, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (160784308..160994681, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene protein phosphatase with EF hand calcium-binding domain 1 Neighboring gene STARR-seq mESC enhancer starr_48184 Neighboring gene nuclear encoded tRNA valine 3 (anticodon TAC) Neighboring gene STARR-seq mESC enhancer starr_48186 Neighboring gene retinoschisis (X-linked, juvenile) 1 (human) Neighboring gene gap junction protein, alpha 6 Neighboring gene STARR-positive B cell enhancer mm9_chrX:157432549-157432849 Neighboring gene STARR-seq mESC enhancer starr_48187 Neighboring gene STARR-seq mESC enhancer starr_48188 Neighboring gene STARR-seq mESC enhancer starr_48189 Neighboring gene STARR-seq mESC enhancer starr_48190 Neighboring gene STARR-seq mESC enhancer starr_48191 Neighboring gene STARR-seq mESC enhancer starr_48192 Neighboring gene STARR-seq mESC enhancer starr_48193 Neighboring gene Scm polycomb group protein like 2 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon TAA) Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 
    • Targeted (12)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables kinase activity PubMed 
    enables protein kinase activity  
    enables protein kinase activity PubMed 
    enables protein serine kinase activity  
    enables small GTPase binding  
    Component Evidence Code Pubs
    located_in centrosome  
    located_in centrosome  
    located_in ciliary basal body  
    located_in ciliary basal body  
    located_in ciliary tip  
    located_in ciliary tip  
    located_in cytoplasm  
    is_active_in dendrite cytoplasm  
    located_in dendrite cytoplasm  
    located_in dendritic growth cone  
    is_active_in glutamatergic synapse  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    is_active_in postsynaptic density, intracellular component  
    located_in ruffle membrane  

    General protein information

    Preferred Names
    cyclin-dependent kinase-like 5
    Names
    serine/threonine kinase 9
    NP_001019795.1
    NP_001408452.1
    NP_001408453.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024624.3NP_001019795.1  cyclin-dependent kinase-like 5 isoform 3

      See identical proteins and their annotated locations for NP_001019795.1

      Status: VALIDATED

      Source sequence(s)
      AL669939, AL670462
      Consensus CDS
      CCDS53238.1
      UniProtKB/Swiss-Prot
      Q05BK3, Q3UTQ8, Q8BWI8
      UniProtKB/TrEMBL
      A0A0G2JF79
      Related
      ENSMUSP00000084342.5, ENSMUST00000087104.11
      Conserved Domains (2) summary
      smart00220
      Location:13297
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07848
      Location:11297
      STKc_CDKL5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5
    2. NM_001421523.1NP_001408452.1  cyclin-dependent kinase-like 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669939, AL670462
      UniProtKB/TrEMBL
      A0A0G2JF79, A0A0G2JGW6
      Related
      ENSMUSP00000143726.2, ENSMUST00000198931.2
    3. NM_001421524.1NP_001408453.1  cyclin-dependent kinase-like 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL669939, AL670462
      UniProtKB/TrEMBL
      A0A0G2JF79

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      159567241..159777673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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