U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    ARHGAP35 Rho GTPase activating protein 35 [ Homo sapiens (human) ]

    Gene ID: 2909, updated on 4-Jan-2025

    Summary

    Official Symbol
    ARHGAP35provided by HGNC
    Official Full Name
    Rho GTPase activating protein 35provided by HGNC
    Primary source
    HGNC:HGNC:4591
    See related
    Ensembl:ENSG00000160007 MIM:605277; AllianceGenome:HGNC:4591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP
    Summary
    The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARHGAP35 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46860997..47005077)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49686835..49830977)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47364254..47508334)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47341466-47341966 Neighboring gene small NF90 (ILF3) associated RNA E Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47358600-47359538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47359539-47360475 Neighboring gene adaptor related protein complex 2 subunit sigma 1 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10834 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:47466169-47467368 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47479369-47480226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47480227-47481082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47505718-47506463 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47506464-47507210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47508684-47509262 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47514658-47514871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10835 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47533967-47534068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47534993-47535494 Neighboring gene neuronal PAS domain protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10836 Neighboring gene transmembrane protein 160

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (39 hits/1284 screens)

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The 3S motif of HIV-1 gp41 activates p190 RhoGAP PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • KIAA1722, MGC10745

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables GTP binding  
    enables GTPase activator activity  
    enables GTPase activator activity PubMed 
    enables GTPase activator activity  
    enables GTPase activity  
    enables phospholipid binding PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    involved_in axon guidance  
    involved_in axonal fasciculation  
    involved_in camera-type eye development  
    involved_in cell migration  
    involved_in central nervous system neuron axonogenesis  
    involved_in establishment or maintenance of actin cytoskeleton polarity  
    involved_in forebrain development  
    involved_in mammary gland development  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction  
    involved_in negative regulation of vascular permeability  
    involved_in neural tube closure  
    involved_in neuron projection guidance  
    involved_in positive regulation of cilium assembly  
    involved_in positive regulation of neuron projection development  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin polymerization or depolymerization  
    involved_in regulation of axonogenesis  
    involved_in regulation of axonogenesis  
    involved_in regulation of cell shape  
    involved_in regulation of cell size  
    involved_in regulation of small GTPase mediated signal transduction  
    involved_in wound healing, spreading of cells  
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    located_in ciliary basal body  
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    rho GTPase-activating protein 35
    Names
    glucocorticoid receptor DNA-binding factor 1
    glucocorticoid receptor repression factor 1
    rho GAP p190A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047014.2 RefSeqGene

      Range
      5001..149081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004491.5 → NP_004482.4  rho GTPase-activating protein 35

      Status: REVIEWED

      Source sequence(s)
      AB051509, AC008755, AC008895, BE871213, CA429690, CX163309
      Consensus CDS
      CCDS46127.1
      UniProtKB/Swiss-Prot
      A7E2A4, Q14452, Q9C0E1, Q9NRY4
      UniProtKB/TrEMBL
      A0A2X0SFV3
      Related
      ENSP00000500409.1, ENST00000672722.1
      Conserved Domains (5) summary
      smart00441
      Location:431 → 483
      FF; Contains two conserved F residues
      smart00173
      Location:158 → 250
      RAS; Ras subfamily of RAS small GTPases
      cd04373
      Location:1247 → 1431
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:261 → 340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cd22221
      Location:594 → 765
      pseudoGTPaseD_p190RhoGAP-A; pseudoGTPase domain found in p190RhoGAP-A and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46860997..47005077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451473.2 → XP_024307241.1  rho GTPase-activating protein 35 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFV3
      Conserved Domains (4) summary
      smart00441
      Location:431 → 483
      FF; Contains two conserved F residues
      cl02570
      Location:1247 → 1380
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      pfam16512
      Location:261 → 340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158 → 250
      Ras; Ras family

    RNA

    1. XR_002958305.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      49686835..49830977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320752.1 → XP_054176727.1  rho GTPase-activating protein 35 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFV3

    RNA

    1. XR_008485136.1 RNA Sequence

    Loading
    External link. Please review our privacy policy.