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    Elavl1 ELAV like RNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 15568, updated on 14-Jan-2025

    Summary

    Official Symbol
    Elavl1provided by MGI
    Official Full Name
    ELAV like RNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1100851
    See related
    Ensembl:ENSMUSG00000040028 AllianceGenome:MGI:1100851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HUR; Hua; 2410055N02Rik
    Summary
    Enables lncRNA binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in post-transcriptional regulation of gene expression; protein import into nucleus; and regulation of stem cell population maintenance. Acts upstream of or within positive regulation of translation. Located in several cellular components, including cytoplasmic stress granule; endoplasmic reticulum; and sarcoplasm. Part of ribonucleoprotein complex. Is active in cytoplasmic vesicle; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; early conceptus; and genitourinary system. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.0), whole brain E14.5 (RPKM 14.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Elavl1 in Genome Data Viewer
    Location:
    8 A1.1; 8 2.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4334781..4375104, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4284781..4325140, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cortexin 1 Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene STARR-positive B cell enhancer ABC_E4988 Neighboring gene predicted gene, 50600 Neighboring gene C-C motif chemokine ligand 25 Neighboring gene predicted gene 7434

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (10)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding  
    enables double-stranded RNA binding PubMed 
    enables lncRNA binding PubMed 
    enables lncRNA binding PubMed 
    enables mRNA 3'-UTR AU-rich region binding PubMed 
    enables mRNA 3'-UTR AU-rich region binding PubMed 
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA 3'-UTR binding PubMed 
    enables mRNA 3'-UTR binding  
    enables mRNA binding PubMed 
    enables mRNA binding  
    enables miRNA binding  
    enables miRNA binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase binding  
    enables protein kinase binding  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization PubMed 
    involved_in 3'-UTR-mediated mRNA stabilization  
    involved_in 3'-UTR-mediated mRNA stabilization  
    involved_in lncRNA-mediated post-transcriptional gene silencing PubMed 
    involved_in mRNA destabilization  
    involved_in mRNA destabilization  
    involved_in mRNA stabilization PubMed 
    acts_upstream_of_or_within mRNA stabilization PubMed 
    involved_in mRNA stabilization PubMed 
    acts_upstream_of_or_within mRNA stabilization PubMed 
    involved_in mRNA stabilization  
    involved_in mRNA stabilization  
    involved_in negative regulation of miRNA-mediated gene silencing  
    involved_in negative regulation of miRNA-mediated gene silencing  
    involved_in positive regulation of superoxide anion generation  
    involved_in positive regulation of superoxide anion generation  
    acts_upstream_of_or_within positive regulation of translation PubMed 
    acts_upstream_of_or_within positive regulation of translation PubMed 
    acts_upstream_of_or_within positive regulation of translation PubMed 
    involved_in post-transcriptional gene silencing PubMed 
    involved_in protein homooligomerization  
    involved_in protein homooligomerization  
    involved_in protein import into nucleus PubMed 
    involved_in regulation of stem cell population maintenance PubMed 
    acts_upstream_of_or_within regulation of translation PubMed 
    Component Evidence Code Pubs
    located_in P-body  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule PubMed 
    is_active_in cytoplasmic vesicle PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    is_active_in postsynapse PubMed 
    is_active_in postsynapse PubMed 
    part_of ribonucleoprotein complex PubMed 
    located_in sarcoplasm PubMed 

    General protein information

    Preferred Names
    ELAV-like protein 1
    Names
    ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
    HU-antigen A
    elav-like generic protein
    hu-antigen R
    melG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010485.3NP_034615.2  ELAV-like protein 1

      See identical proteins and their annotated locations for NP_034615.2

      Status: VALIDATED

      Source sequence(s)
      AC155164, AK028769, AK080365, BB305633, BY775007
      Consensus CDS
      CCDS22084.1
      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Related
      ENSMUSP00000096549.5, ENSMUST00000098950.6
      Conserved Domains (1) summary
      TIGR01661
      Location:19326
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4334781..4375104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508698.5XP_006508761.1  ELAV-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508761.1

      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Conserved Domains (1) summary
      TIGR01661
      Location:19326
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    2. XM_030243302.2XP_030099162.1  ELAV-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Conserved Domains (1) summary
      TIGR01661
      Location:19326
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    3. XM_030243301.2XP_030099161.1  ELAV-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Related
      ENSMUSP00000146866.2, ENSMUST00000209010.2
      Conserved Domains (1) summary
      TIGR01661
      Location:19326
      ELAV_HUD_SF; ELAV/HuD family splicing factor
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