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    RPS6KA4 ribosomal protein S6 kinase A4 [ Homo sapiens (human) ]

    Gene ID: 8986, updated on 3-Dec-2024

    Summary

    Official Symbol
    RPS6KA4provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase A4provided by HGNC
    Primary source
    HGNC:HGNC:10433
    See related
    Ensembl:ENSG00000162302 MIM:603606; AllianceGenome:HGNC:10433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSK2; RSK-B; S6K-alpha-4
    Summary
    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in spleen (RPKM 12.2), colon (RPKM 9.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS6KA4 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64359162..64372215)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64349167..64362217)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64126634..64139687)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723878 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64092812-64092964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64098506-64099028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4899 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3479 Neighboring gene Sharpr-MPRA regulatory region 2125 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64126659-64127186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64136631-64137150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64140451-64141006 Neighboring gene microRNA 1237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64141007-64141560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64146667-64147284 Neighboring gene uncharacterized LOC124902688 Neighboring gene long intergenic non-protein coding RNA 2723

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3S28 kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-4
    Names
    90 kDa ribosomal protein S6 kinase 4
    mitogen- and stress-activated protein kinase 2
    nuclear mitogen- and stress-activated protein kinase 2
    ribosomal protein S6 kinase, 90kDa, polypeptide 4
    ribosomal protein kinase B
    NP_001006945.1
    NP_001287731.1
    NP_001305290.1
    NP_003933.1
    XP_005274437.1
    XP_047283799.1
    XP_047283800.1
    XP_054226401.1
    XP_054226402.1
    XP_054226403.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006944.2NP_001006945.1  ribosomal protein S6 kinase alpha-4 isoform b

      See identical proteins and their annotated locations for NP_001006945.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform b).
      Source sequence(s)
      AF074715, AJ010119, BI523588
      UniProtKB/TrEMBL
      A0A0A6YYC0
      Related
      ENSP00000432945.1, ENST00000530504.1
      Conserved Domains (3) summary
      smart00220
      Location:33301
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05614
      Location:32364
      STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
      cl21453
      Location:400708
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001300802.2NP_001287731.1  ribosomal protein S6 kinase alpha-4 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform c).
      Source sequence(s)
      AJ010119, AK223561, AK313567, AP003774
      Consensus CDS
      CCDS73313.1
      UniProtKB/TrEMBL
      A0A0A6YYC0, E9PJN1
      Related
      ENSP00000435580.1, ENST00000528057.5
      Conserved Domains (3) summary
      smart00220
      Location:33301
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05614
      Location:32364
      STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
      cl21453
      Location:400707
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001318361.2NP_001305290.1  ribosomal protein S6 kinase alpha-4 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AJ010119, AK298507, AP003774, BI253655
      UniProtKB/TrEMBL
      B4DPV1
      Conserved Domains (2) summary
      smart00220
      Location:354611
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1301
      PKc_like; Protein Kinases, catalytic domain
    4. NM_003942.3NP_003933.1  ribosomal protein S6 kinase alpha-4 isoform a

      See identical proteins and their annotated locations for NP_003933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AJ010119, BC028079, BI523588
      Consensus CDS
      CCDS8073.1
      UniProtKB/Swiss-Prot
      A8K7Z8, O75585, O75676, Q53ES8
      UniProtKB/TrEMBL
      B4DPV1
      Related
      ENSP00000333896.4, ENST00000334205.9
      Conserved Domains (3) summary
      smart00220
      Location:33301
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05614
      Location:32364
      STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
      cl21453
      Location:404714
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64359162..64372215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274380.2XP_005274437.1  ribosomal protein S6 kinase alpha-4 isoform X1

      UniProtKB/TrEMBL
      B4DPV1
      Conserved Domains (1) summary
      cl21453
      Location:32308
      PKc_like; Protein Kinases, catalytic domain
    2. XM_047427843.1XP_047283799.1  ribosomal protein S6 kinase alpha-4 isoform X2

      UniProtKB/TrEMBL
      A0A0A6YYC0
    3. XM_047427844.1XP_047283800.1  ribosomal protein S6 kinase alpha-4 isoform X3

      UniProtKB/TrEMBL
      A0A0A6YYC0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64349167..64362217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370426.1XP_054226401.1  ribosomal protein S6 kinase alpha-4 isoform X1

      UniProtKB/TrEMBL
      B4DPV1
    2. XM_054370427.1XP_054226402.1  ribosomal protein S6 kinase alpha-4 isoform X2

      UniProtKB/TrEMBL
      A0A0A6YYC0
    3. XM_054370428.1XP_054226403.1  ribosomal protein S6 kinase alpha-4 isoform X3

      UniProtKB/TrEMBL
      A0A0A6YYC0