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    POP7 POP7 homolog, ribonuclease P/MRP subunit [ Homo sapiens (human) ]

    Gene ID: 10248, updated on 27-Nov-2024

    Summary

    Official Symbol
    POP7provided by HGNC
    Official Full Name
    POP7 homolog, ribonuclease P/MRP subunitprovided by HGNC
    Primary source
    HGNC:HGNC:19949
    See related
    Ensembl:ENSG00000172336 MIM:606113; AllianceGenome:HGNC:19949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPP2; RPP20; 0610037N12Rik
    Summary
    Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 11.3), brain (RPKM 11.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See POP7 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100706121..100707486)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101946186..101947551)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100303744..100305109)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26381 Neighboring gene G protein subunit beta 2 Neighboring gene GRB10 interacting GYF protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18459 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3567 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100292979-100293782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26382 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100322454-100322688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26383 Neighboring gene erythropoietin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26384 Neighboring gene zonadhesin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100382347-100382846 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:100391649-100392196

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonuclease P RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA 5'-leader removal IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    part_of multimeric ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleolar ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ribonuclease P protein subunit p20
    Names
    POP7 (processing of precursor, S. cerevisiae) homolog
    RNaseP protein p20
    hPOP7
    processing of precursor 7, ribonuclease P subunit
    processing of precursor 7, ribonuclease P/MRP subunit
    ribonucleases P/MRP protein subunit POP7 homolog
    NP_005828.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005837.3NP_005828.2  ribonuclease P protein subunit p20

      See identical proteins and their annotated locations for NP_005828.2

      Status: VALIDATED

      Source sequence(s)
      BC001430, BI666854
      Consensus CDS
      CCDS5704.1
      UniProtKB/Swiss-Prot
      A4D2E0, O75817, Q9BV74
      UniProtKB/TrEMBL
      C9JYM0
      Related
      ENSP00000304353.4, ENST00000303151.5
      Conserved Domains (1) summary
      pfam12328
      Location:33133
      Rpp20; Rpp20 subunit of nuclear RNase MRP and P

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100706121..100707486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101946186..101947551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)