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    ALP1 arginine permease ALP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ALP1
    Official Full Name
    arginine permease ALP1
    Primary source
    SGD:S000005214
    Locus tag
    YNL270C
    See related
    AllianceGenome:SGD:S000005214; FungiDB:YNL270C; VEuPathDB:YNL270C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APL1
    Summary
    Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ALP1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (135940..137661, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene guanine nucleotide exchange factor SEC2 Neighboring gene formin BNI1 Neighboring gene Bsc4p Neighboring gene lysine permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport in isolated yeast vacuoles: characterization of arginine permease. Boller T, et al. Methods Enzymol, 1989. PMID 2698990
    2. APL1, a yeast gene encoding a putative permease for basic amino acids. Sychrova H, et al. Yeast, 1994 May. PMID 7941748
    3. The sequence of a 24,152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes. Sen-Gupta M, et al. Yeast, 1996 Apr. PMID 8740425
    4. Effects of three permeases on arginine utilization in Saccharomyces cerevisiae. Zhang P, et al. Sci Rep, 2016 Feb 11. PMID 26865023, Free PMC Article
    5. Metabolic engineering of arginine permeases to reduce the formation of urea in Saccharomyces cerevisiae. Zhang P, et al. World J Microbiol Biotechnol, 2018 Mar 13. PMID 29536194

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables basic amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arginine permease ALP1
    NP_014129.1
    • Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      135940..137661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183108.1 → NP_014129.1  TPA: arginine permease ALP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0S4, P38971
      UniProtKB/TrEMBL
      B3LPA9, C7GP93, C8ZFW9
      Conserved Domains (1) summary
      TIGR00913
      Location:67 → 545
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38971.2

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