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    APM1 Apm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APM1
    Official Full Name
    Apm1p
    Primary source
    SGD:S000006180
    Locus tag
    YPL259C
    See related
    AllianceGenome:SGD:S000006180; FungiDB:YPL259C; VEuPathDB:YPL259C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YAP54
    Summary
    Predicted to enable clathrin adaptor activity. Involved in Golgi to vacuole transport. Part of AP-1 adaptor complex. Orthologous to several human genes including AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APM1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (51244..52671, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene fumarase FUM1 Neighboring gene uncharacterized protein Neighboring gene Cub1p Neighboring gene ncRNA Neighboring gene bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Nakayama Y, et al. Eur J Biochem, 1991 Dec 5. PMID 1761056
    2. A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Stepp JD, et al. Mol Biol Cell, 1995 Jan. PMID 7749194, Free PMC Article
    3. Efficient ER exit and vacuole targeting of yeast Sna2p require two tyrosine-based sorting motifs. Renard HF, et al. Traffic, 2010 Jul 1. PMID 20406419
    4. Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast. Kita A, et al. Mol Biol Cell, 2004 Jun. PMID 15047861, Free PMC Article
    5. The clathrin adaptor complex 1 directly binds to a sorting signal in Ste13p to reduce the rate of its trafficking to the late endosome of yeast. Foote C, et al. J Cell Biol, 2006 May 22. PMID 16702232, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role for Apm1 associated with the Golgi/endosome function, thereby affecting various cellular processes, including secretion, cytokinesis, vacuole fusion, and cell integrity; and also calcineurin is involved in these events
      Title: Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apm1p
    NP_015064.1
    • Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      51244..52671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184073.1 → NP_015064.1  TPA: Apm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3B0, Q00776
      UniProtKB/TrEMBL
      B3LKH3, B5VSS8, C7GSG1, N1NVV9
      Conserved Domains (2) summary
      cd09250
      Location:161 → 471
      AP-1_Mu1_Cterm; C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1
      cd14835
      Location:3 → 143
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00776.2

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