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    LINC00470 long intergenic non-protein coding RNA 470 [ Homo sapiens (human) ]

    Gene ID: 56651, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00470provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 470provided by HGNC
    Primary source
    HGNC:HGNC:1225
    See related
    AllianceGenome:HGNC:1225
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C18orf2
    Expression
    Biased expression in testis (RPKM 1.4), placenta (RPKM 1.0) and 1 other tissue See more
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    Genomic context

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    See LINC00470 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (1268311..1359629, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (1422813..1514125, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (1268312..1359630, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371953 Neighboring gene solute carrier family 25 member 3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 5202 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:1208318-1209041 Neighboring gene MPRA-validated peak3040 silencer Neighboring gene RN7SK pseudogene 72 Neighboring gene ATPase family AAA domain containing 1 pseudogene Neighboring gene uncharacterized LOC105371954 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:1369016-1369234 Neighboring gene uncharacterized LOC105371960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma. Wu C, et al. J Cell Mol Med, 2020 Oct. PMID 32916774, Free PMC Article
    2. LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma. Huang W, et al. Hum Cell, 2020 Jan. PMID 31612313
    3. LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression. Huang T, et al. Cell Death Dis, 2021 Apr 19. PMID 33875645, Free PMC Article
    4. Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells. Lai X, et al. J Cell Mol Med, 2021 May. PMID 33749070, Free PMC Article
    5. LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells. Yan J, et al. Biochem Biophys Res Commun, 2020 Jan 22. PMID 31711642

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2.
      Title: Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2.
    2. LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
      Title: LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
    3. Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells.
      Title: Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells.
    4. LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma.
      Title: LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma.
    5. LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma.
      Title: LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma.
    6. LINC00470 is upregulated in the gastric cancer tissues and promotes GC cell proliferation, migration and invasion.LINC00470 associated with PTEN mRNA and suppressed its stability through interaction with the N(6)-methyladenosine (m(6)A) writer METTL3.
      Title: LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_023925.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AF295725, AF295730, AK057505, AP000829

    2. NR_023926.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon and uses an alternate splice site, compared to variant 1.
      Source sequence(s)
      AF295725, AF295726, AF295730, AK057505, AP000829

    3. NR_023927.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks internal exons, compared to variant 1.
      Source sequence(s)
      AF295730, AK057505, AP000829

    4. NR_110327.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks internal exons, compared to variant 1.
      Source sequence(s)
      AP000829, AP005119

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      1268311..1359629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      1422813..1514125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031416.2: Suppressed sequence

      Description
      NM_031416.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZP3.1 GenPept UniProtKB/Swiss-Prot:Q9BZP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials