Ccl25 C-C motif chemokine ligand 25 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl25provided by MGI
Official Full Name: C-C motif chemokine ligand 25provided by MGI
Primary source: MGI:MGI:1099448
See related: Ensembl:ENSMUSG00000023235 AllianceGenome:MGI:1099448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TECK; CKb15; Scya25; A130072A22Rik
Summary: Enables chemokine activity. Acts upstream of or within chemotaxis; leukocyte migration; and lymphoid lineage cell migration. Predicted to be active in extracellular space. Is expressed in 3rd branchial pouch; central nervous system; hemolymphoid system; retina; and thymus/parathyroid primordium. Orthologous to human CCL25 (C-C motif chemokine ligand 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 91.4), thymus adult (RPKM 40.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 2.01 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (4375207..4410020)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (4325205..4360020)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Piezo1 activation on microglial cells exacerbates demyelination in sepsis by influencing the CCL25/GRP78 pathway.
Title: Piezo1 activation on microglial cells exacerbates demyelination in sepsis by influencing the CCL25/GRP78 pathway.
ZIM3 activation of CCL25 expression in pulmonary metastatic nodules of osteosarcoma recruits M2 macrophages to promote metastatic growth.
Title: ZIM3 activation of CCL25 expression in pulmonary metastatic nodules of osteosarcoma recruits M2 macrophages to promote metastatic growth.
The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo.
Title: The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo.
Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis.
Title: Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis.
Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis.
Title: Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis.
these results showed a site- and cell-specific expressions of Ccl25 and its receptor Ccr9 within both maternal and embryonic compartments of implantation sites and suggested a role in inducing specific Ccr9+ leukocytes at the maternal-fetal interface during the initial steps of embryo implantation in the mouse model
Title: Chemokine (C-C motif) ligand 25 expressed by trophoblast cells and leukocytes bearing its receptor Ccr9: An alliance during embryo implantation?
MicroRNA-205 maintains T cell development following stress by regulating Foxn1 and its two regulated targets, stem cell factor and ccl25, following stress.
Title: MicroRNA-205 Maintains T Cell Development following Stress by Regulating Forkhead Box N1 and Selected Chemokines.
CCR9 and CCL25 expressions are induced in the early stages of airway inflammation and they have an important role modulating eosinophils and lymphocytes recruitment at the first stages of inflammatory process
Title: CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation.
TECK was shown to be expressed by osteoblasts, and its receptor, CCR9, by osteoclast precursors. TECK increased P. gingivalis LPS-induced osteoclast numbers in an in vitro osteoclast formation assay using osteoclast precursors. T
Title: Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation.
CCR9/CCL25 is involved in acute skin transplantation rejection and anti-CCL25 strategies might be useful in preventing acute rejection.
Title: Anti-CCL25 antibody prolongs skin allograft survival by blocking CCR9 expression and impairing splenic T-cell function.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491276

RH125542 (e-PCR)
- UniSTS:162357

Ccl25 (e-PCR), detects polymorphism
- UniSTS:530817

AI852536 (e-PCR)
- UniSTS:179692

Ccl25 (e-PCR), detects polymorphism
- UniSTS:526070

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR10 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lymphoid lineage cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-C motif chemokine 25

Names: chemokine (C-C motif) ligand 25; small inducible chemokine 25; small inducible cytokine A25; thymus-expressed chemokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009138.3 → NP_033164.1 C-C motif chemokine 25 precursor

See identical proteins and their annotated locations for NP_033164.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

AK131875, AK134138, DQ158256

Consensus CDS

CCDS22085.1

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Related

ENSMUSP00000024004.8, ENSMUST00000024004.9

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...

RNA

NR_033527.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons and includes two alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AK132700, DQ158256

Related

ENSMUST00000155797.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

4375207..4410020

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508736.5 → XP_006508799.1 C-C motif chemokine 25 isoform X2

UniProtKB/TrEMBL

D3YWJ1

Related

ENSMUSP00000120719.3, ENSMUST00000127460.8

Conserved Domains (1) summary

cd01119
Location:112 → 173

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_030243364.1 → XP_030099224.1 C-C motif chemokine 25 isoform X4

Conserved Domains (1) summary

cd01119
Location:81 → 142

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153845.1 → XP_036009738.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153847.1 → XP_036009740.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153840.1 → XP_036009733.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153843.1 → XP_036009736.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153848.1 → XP_036009741.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153841.1 → XP_036009734.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153846.1 → XP_036009739.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_011242043.3 → XP_011240345.3 C-C motif chemokine 25 isoform X1

Conserved Domains (1) summary

cd01119
Location:117 → 178

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_011242044.4 → XP_011240346.3 C-C motif chemokine 25 isoform X3

Conserved Domains (1) summary

cd01119
Location:86 → 147

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_011242045.3 → XP_011240347.1 C-C motif chemokine 25 isoform X5

Conserved Domains (1) summary

cd01119
Location:45 → 106

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153844.1 → XP_036009737.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
XM_036153842.1 → XP_036009735.1 C-C motif chemokine 25 isoform X6

UniProtKB/Swiss-Prot

O35903, Q9QYY6

UniProtKB/TrEMBL

Q3V2F3

Conserved Domains (1) summary

cd01119
Location:28 → 89

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...