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    PF3D7_0211200 ras-related protein Rab-5A [ Plasmodium falciparum 3D7 ]

    Gene ID: 812700, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0211200
    Gene description
    ras-related protein Rab-5A
    Locus tag
    PF3D7_0211200
    See related
    PlasmoDB:PF3D7_0211200; VEuPathDB:PF3D7_0211200
    Gene type
    protein coding
    RNA name
    ras-related protein Rab-5A
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0211200 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_037280.1 (455579..456286, complement)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene ubiquinol-cytochrome-c reductase complex assembly factor 1, putative Neighboring gene beta-ketoacyl-ACP synthase III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural plasticity mediates distinct GAP-dependent GTP hydrolysis mechanisms in Rab33 and Rab5. Majumdar S, et al. FEBS J, 2017 Dec. PMID 29095572
    2. Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum. Elliott DA, et al. Proc Natl Acad Sci U S A, 2008 Feb 19. PMID 18263733, Free PMC Article
    3. Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum. Howe R, et al. Eukaryot Cell, 2013 Feb. PMID 23223036, Free PMC Article
    4. Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites. Rached FB, et al. Biol Cell, 2012 Jan. PMID 22188458, Free PMC Article
    5. The Plasmodium falciparum family of Rab GTPases. Quevillon E, et al. Gene, 2003 Mar 13. PMID 12657463

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of vacuole fusion, non-autophagic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-related protein Rab-5A
    XP_001349618.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      455579..456286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349582.1 → XP_001349618.1  ras-related protein Rab-5A [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349618.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024VD09, A0A024WEG6, A0A024WXI2, A0A024XFS7, A0A0L7K7L5, A0A0L7M5Q0, O96193, W4IQE3, W4J894, W7FEV3, W7FWS6, W7JJW3, W7JN63
      Conserved Domains (1) summary
      cd01860
      Location:6 → 202
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    Nucleotide Protein
    Heading Accession and Version

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