U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PF3D7_0315200 circumsporozoite- and TRAP-related protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 814465, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PF3D7_0315200
    Gene description
    circumsporozoite- and TRAP-related protein
    Locus tag
    PF3D7_0315200
    See related
    PlasmoDB:PF3D7_0315200; VEuPathDB:PF3D7_0315200
    Gene type
    protein coding
    RNA name
    circumsporozoite- and TRAP-related protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PF3D7_0315200 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_000521.4 (616472..622816)

    Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein, putative Neighboring gene eukaryotic translation initiation factor 4E Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000521.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis. Lin LY, et al. Malar J, 2021 Mar 2. PMID 33653360, Free PMC Article
    2. Developmental arrest of the human malaria parasite Plasmodium falciparum within the mosquito midgut via CTRP gene disruption. Templeton TJ, et al. Mol Microbiol, 2000 Apr. PMID 10760158
    3. Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate. Plassmeyer ML, et al. J Biol Chem, 2009 Sep 25. PMID 19633296, Free PMC Article
    4. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, et al. Nature, 1999 Aug 5. PMID 10448855
    5. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis.
      Title: Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables GPI anchor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparan sulfate proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    circumsporozoite- and TRAP-related protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000521.4 Reference assembly

      Range
      616472..622816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351185.1 → XP_001351221.1  circumsporozoite- and TRAP-related protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351221.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0L0CTX0, A0A2I0BTH5, O97267
      Conserved Domains (7) summary
      smart00209
      Location:1597 → 1646
      TSP1; Thrombospondin type 1 repeats
      cd01473
      Location:304 → 494
      vWA_CTRP; CTRP for CS protein-TRAP-related protein: Adhesion of Plasmodium to host cells is an important phenomenon in parasite invasion and in malaria associated pathology.CTRP encodes a protein containing a putative signal sequence followed by a long ...
      pfam02389
      Location:752 → 837
      Cornifin; Cornifin (SPRR) family
      pfam00092
      Location:1303 → 1455
      VWA; von Willebrand factor type A domain
      pfam19028
      Location:1654 → 1703
      TSP1_spondin; Spondin-like TSP1 domain
      NF033839
      Location:499 → 553
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
      cl00057
      Location:1066 → 1255
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous