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    PF3D7_0302600 ABC transporter B family member 4, putative [ Plasmodium falciparum 3D7 ]

    Gene ID: 814343, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_0302600
    Gene description
    ABC transporter B family member 4, putative
    Locus tag
    PF3D7_0302600
    See related
    PlasmoDB:PF3D7_0302600; VEuPathDB:PF3D7_0302600
    Gene type
    protein coding
    RNA name
    ABC transporter B family member 4, putative
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_0302600 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_000521.4 (141556..145653)

    Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytoadherence linked asexual protein 3.1 Neighboring gene CDGSH iron-sulfur domain-containing protein, putative Neighboring gene RNA-binding protein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000521.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Absence of correlation between ex vivo susceptibility to doxycycline and pfteQ-pfmdt gene polymorphism in French Guiana. Mura M, et al. Malar J, 2015 Jul 25. PMID 26206143, Free PMC Article
    2. Susceptibility of Plasmodium falciparum isolates to doxycycline is associated with pftetQ sequence polymorphisms and pftetQ and pfmdt copy numbers. Briolant S, et al. J Infect Dis, 2010 Jan 1. PMID 19929377
    3. A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites. Sayers CP, et al. Cell Microbiol, 2018 Jan. PMID 28902970
    4. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Cowell AN, et al. Science, 2018 Jan 12. PMID 29326268, Free PMC Article
    5. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, et al. Nature, 1999 Aug 5. PMID 10448855

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PftetQ and pfmdt copy numbers were not associated with reduced susceptibility to doxycycline in P. falciparum within French Guiana. Sequence analysis of the genes revealed five known single nucleotide polymorphisms.
      Title: Absence of correlation between ex vivo susceptibility to doxycycline and pfteQ-pfmdt gene polymorphism in French Guiana.
    2. We found that pfmdt (Plasmodium falciparum multidrug resistance gene) copy number was associated with decreased susceptibility to doxycycline
      Title: Susceptibility of Plasmodium falciparum isolates to doxycycline is associated with pftetQ sequence polymorphisms and pftetQ and pfmdt copy numbers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicoplast HDA PubMed 
    located_in apicoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ABC transporter B family member 4, putative

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000521.4 Reference assembly

      Range
      141556..145653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351065.1 → XP_001351101.1  ABC transporter B family member 4, putative [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351101.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0L7KBA1, O77308, W7G168, W7K1K2
      Conserved Domains (3) summary
      COG2274
      Location:980 → 1352
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
      cl38913
      Location:173 → 483
      ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
      cl38936
      Location:1235 → 1354
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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