U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PF3D7_0500800 mature parasite-infected erythrocyte surface antigen [ Plasmodium falciparum 3D7 ]

    Gene ID: 812891, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PF3D7_0500800
    Gene description
    mature parasite-infected erythrocyte surface antigen
    Locus tag
    PF3D7_0500800
    See related
    PlasmoDB:PF3D7_0500800; VEuPathDB:PF3D7_0500800
    Gene type
    protein coding
    RNA name
    mature parasite-infected erythrocyte surface antigen
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PF3D7_0500800 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_004326.2 (43327..47761, complement)

    Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene serine/threonine protein kinase, FIKK family Neighboring gene Plasmodium exported protein, unknown function

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_004326.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. In vivo studies support the role of trafficking and cytoskeletal-binding motifs in the interaction of MESA with the membrane skeleton of Plasmodium falciparum-infected red blood cells. Black CG, et al. Mol Biochem Parasitol, 2008 Aug. PMID 18482775, Free PMC Article
    2. Two approximately 300 kilodalton Plasmodium falciparum proteins at the surface membrane of infected erythrocytes. Howard RJ, et al. Mol Biochem Parasitol, 1988 Jan 15. PMID 3278227
    3. MESA is a Plasmodium falciparum phosphoprotein associated with the erythrocyte membrane skeleton. Coppel RL, et al. Mol Biochem Parasitol, 1988 Dec. PMID 3065643
    4. The Plasmodium falciparum MESA erythrocyte cytoskeleton-binding (MEC) motif binds to erythrocyte ankyrin. Kilili GK, et al. Mol Biochem Parasitol, 2019 Jul. PMID 31125575, Free PMC Article
    5. Proteome and Structural Organization of the Knob Complex on the Surface of the Plasmodium Infected Red Blood Cell. Alampalli SV, et al. Proteomics Clin Appl, 2018 Jul. PMID 28981210

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved aspartic acid residue at the C-terminus of the MEC motif for MESA binding to erythrocyte ANK1.
      Title: The Plasmodium falciparum MESA erythrocyte cytoskeleton-binding (MEC) motif binds to erythrocyte ankyrin.
    2. MESA has a 4.1R binding sequence SIRNY--C---APYI which is similar to the SMKNY--C---APYI motif in the RESA-like protein.
      Title: Myosin-like sequences in the malaria parasite Plasmodium falciparum bind human erythrocyte membrane protein 4.1.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in host cell plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in infected host cell surface knob IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    mature parasite-infected erythrocyte surface antigen

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004326.2 Reference assembly

      Range
      43327..47761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001351531.1 → XP_001351567.1  mature parasite-infected erythrocyte surface antigen [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001351567.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I0BTZ4, Q8I492
      Conserved Domains (2) summary
      pfam06513
      Location:523 → 727
      DUF1103; Repeat of unknown function (DUF1103)
      pfam00226
      Location:1337 → 1400
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials