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    SNF5 Snf5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852592, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNF5
    Official Full Name
    Snf5p
    Primary source
    SGD:S000000493
    Locus tag
    YBR289W
    See related
    AllianceGenome:SGD:S000000493; FungiDB:YBR289W; VEuPathDB:YBR289W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HAF4; SWI10; TYE4
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including carbon catabolite activation of transcription from RNA polymerase II promoter; double-strand break repair via homologous recombination; and positive regulation of invasive growth in response to glucose limitation. Located in cytosol and nucleus. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; central nervous system cancer (multiple); rhabdoid cancer; and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNF5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (779667..782384)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Apm3p Neighboring gene Bsd2p Neighboring gene Ctp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of glutamine-rich transactivation function between yeast and humans. Escher D, et al. Mol Cell Biol, 2000 Apr. PMID 10733580, Free PMC Article
    2. Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins. Chavali S, et al. Nat Struct Mol Biol, 2017 Sep. PMID 28805808, Free PMC Article
    3. Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex. Sen P, et al. Cell Rep, 2017 Feb 28. PMID 28249160, Free PMC Article
    4. Essential roles of Snf5p in Snf-Swi chromatin remodeling in vivo. Geng F, et al. Mol Cell Biol, 2001 Jul. PMID 11390659, Free PMC Article
    5. The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes. Laurent BC, et al. Mol Cell Biol, 1990 Nov. PMID 2233708, Free PMC Article

    See all (178) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that the SWI/SNF chromatin-remodeling complex is recruited to DNA lesions by damage-recognition proteins to increase DNA accessibility for NER in chromatin.
      Title: Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair.
    2. This strongly suggests that the SNF5 homology domain presents species-specific functions.
      Title: Complementation analyses suggest species-specific functions of the SNF5 homology domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbon catabolite activation of transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Snf5p
    NP_009848.4
    • Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      779667..782384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178637.4 → NP_009848.4  TPA: Snf5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009848.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQT4, P18480
      UniProtKB/TrEMBL
      A6ZLM7, N1PAW8
      Conserved Domains (1) summary
      pfam04855
      Location:452 → 662
      SNF5; SNF5 / SMARCB1 / INI1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18480.3

    Gene LinkOut

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