Mms19 MMS19 cytosolic iron-sulfur assembly component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mms19provided by MGI
Official Full Name: MMS19 cytosolic iron-sulfur assembly componentprovided by MGI
Primary source: MGI:MGI:1919449
See related: Ensembl:ENSMUSG00000025159 AllianceGenome:MGI:1919449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mms19l; 2410001K24Rik; 2610042O15Rik
Summary: Enables enzyme binding activity. Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Is expressed in several structures, including apical ectodermal ridge; liver; nervous system; neural retina; and trunk somite. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 24.9), ovary adult (RPKM 20.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 35.49 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41932146..41969603, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41943707..41981164, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
Title: The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
in the absence of MMS19, a failure to transfer Fe-S clusters to target proteins is associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been knocked out; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair
Title: MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
Mms19 has distinct and separable functions in nucleotide excision repair and cell growth
Title: Mms19 protein functions in nucleotide excision repair by sustaining an adequate cellular concentration of the TFIIH component Rad3.
Cloning of the mouse MMS19 genes and functional complementation in Saccharomyces cerevisiae
Title: Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C86341 (e-PCR)
- UniSTS:186154

C79368 (e-PCR)
- UniSTS:160836

RH136137 (e-PCR)
- UniSTS:210132

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by iron-sulfur cluster transfer	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by iron-sulfur cluster transfer	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of MMXD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MMXD complex	ISO Inferred from Sequence Orthology more info
part_of MMXD complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly targeting complex	ISO Inferred from Sequence Orthology more info
part_of cytosolic [4Fe-4S] assembly targeting complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: MMS19 nucleotide excision repair protein homolog

Names: MET18 homolog; MMS19 (MET18 S. cerevisiae); MMS19-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001373946.1 → NP_001360875.1 MMS19 nucleotide excision repair protein homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC140193

UniProtKB/TrEMBL

F7C9N6

Related

ENSMUSP00000026168.3, ENSMUST00000026168.9

Conserved Domains (2) summary

pfam12460
Location:527 → 962

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:54 → 312

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
NM_028152.3 → NP_082428.1 MMS19 nucleotide excision repair protein homolog isoform 1

See identical proteins and their annotated locations for NP_082428.1

Status: VALIDATED

Source sequence(s)

AC140193

Consensus CDS

CCDS29818.1

UniProtKB/Swiss-Prot

F8WHX3, Q925N8, Q9CWX3, Q9D071

UniProtKB/TrEMBL

F7C9N6

Related

ENSMUSP00000130900.2, ENSMUST00000171561.8

Conserved Domains (2) summary

pfam12460
Location:528 → 963

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:54 → 312

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

RNA

NR_164197.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC140193

Related

ENSMUST00000163398.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

41932146..41969603 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247350.3 → XP_011245652.1 MMS19 nucleotide excision repair protein homolog isoform X2

UniProtKB/TrEMBL

F7C9N6

Conserved Domains (2) summary

pfam12460
Location:374 → 809

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:26 → 158

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
XM_030251078.2 → XP_030106938.1 MMS19 nucleotide excision repair protein homolog isoform X5

Conserved Domains (1) summary

pfam12460
Location:163 → 598

MMS19_C; RNAPII transcription regulator C-terminal
XM_030251082.2 → XP_030106942.1 MMS19 nucleotide excision repair protein homolog isoform X6

Conserved Domains (1) summary

pfam12460
Location:162 → 597

MMS19_C; RNAPII transcription regulator C-terminal
XM_030251081.2 → XP_030106941.1 MMS19 nucleotide excision repair protein homolog isoform X5

Conserved Domains (1) summary

pfam12460
Location:163 → 598

MMS19_C; RNAPII transcription regulator C-terminal
XM_030251080.1 → XP_030106940.1 MMS19 nucleotide excision repair protein homolog isoform X5

Conserved Domains (1) summary

pfam12460
Location:163 → 598

MMS19_C; RNAPII transcription regulator C-terminal
XM_030251079.1 → XP_030106939.1 MMS19 nucleotide excision repair protein homolog isoform X5

Conserved Domains (1) summary

pfam12460
Location:163 → 598

MMS19_C; RNAPII transcription regulator C-terminal
XM_011247349.4 → XP_011245651.1 MMS19 nucleotide excision repair protein homolog isoform X1

See identical proteins and their annotated locations for XP_011245651.1

UniProtKB/TrEMBL

F7C9N6

Related

ENSMUST00000171755.8

Conserved Domains (2) summary

pfam12460
Location:528 → 886

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:54 → 312

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
XM_011247348.4 → XP_011245650.1 MMS19 nucleotide excision repair protein homolog isoform X1

See identical proteins and their annotated locations for XP_011245650.1

UniProtKB/TrEMBL

F7C9N6

Conserved Domains (2) summary

pfam12460
Location:528 → 886

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:54 → 312

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
XM_017318292.3 → XP_017173781.1 MMS19 nucleotide excision repair protein homolog isoform X4

Conserved Domains (2) summary

pfam12460
Location:527 → 804

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:54 → 312

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
XM_011247351.4 → XP_011245653.1 MMS19 nucleotide excision repair protein homolog isoform X3

Conserved Domains (2) summary

pfam12460
Location:528 → 805

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:54 → 312

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II